Sildenafil Prices, Coupons, Copay Cards & Patient Assistance
It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease).
| Parameter | Value | Notes |
|---|---|---|
| Absorption Rate | Rapid (within 30-60 min) | After oral ingestion |
| Bioavailability | About 40% | Variable depending on food intake |
| Peak Plasma Time | 60 min | Approximate, varies among individuals |
| Half-life | 4-5 hours | Duration of activity |
| Metabolism | Liver via CYP3A4 | Accelerated with certain drugs |
| Excretion | Mainly feces | Small amount in urine |
[56] The first clinical trials were conducted in Morriston Hospital in Swansea.
Before taking this medicine
Sildenafil and/or N-desmethylsildenafil, its major active metabolite, may be quantified in plasma, serum, or whole blood to assess pharmacokinetic status in those receiving the drug therapeutically, to confirm the diagnosis in potential poisoning victims, or to assist in the forensic investigation in a case of fatal overdose. Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue of the penis, causing an erection. [49] Robert F. Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.
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The molecular mechanism of smooth muscle relaxation involves the enzyme CGMP-dependent protein kinase, also known as PKG. This kinase is activated by cGMP and it phosphorylates multiple targets in the smooth muscle cells, namely myosin light chain phosphatase, RhoA, IP3 receptor, phospholipase C, and others. [50] Overall, this results in a decrease in intracellular calcium and desensitizing proteins to the effects of calcium, engendering smooth muscle relaxation. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and increased penile response to sexual stimulation. [49][51] Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. [57] Phase I clinical trials under the direction of Ian Osterloh suggested the drug had little effect on angina, but it could induce marked penile erections.
- Sildenafil 5mg can be used as part of a treatment plan.
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- The pill’s packaging should be intact and sealed.
- Sildenafil 5mg helps men regain confidence in intimacy.
- Consult your healthcare provider if unsure about use.
- The medication may cause temporary vision changes.
- Be aware of the risk of allergic reactions.
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- It’s advised to avoid heavy meals before taking the drug.
- Proper hydration can help minimize side effects.
- Use sildenafil responsibly within prescribed limits.
- Keep a record of dosage and effects for medical review.
[58][59] Pfizer therefore decided to market it for erectile dysfunction, rather than for angina; this decision became an often-cited example of drug repositioning.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 25mg | 10 Pills | 25.19€ 23.99€ | |
| Kamagra Oral Jelly | 100mg | 10 Sachets | 54.55€ 51.95€ | |
| Kamagra Polo | 100mg | 180 + 8 Pills | 446.52€ 425.26€ | |
| Viagra Generic | 25mg | 360 + 10 Pills | 213.68€ 203.50€ | |
| Viagra Generic | 25mg | 20 Pills | 37.74€ 35.94€ | |
| Kamagra Oral Jelly | 100mg | 21 Sachets | 95.92€ 91.35€ | |
| Viagra Generic | 150mg | 20 Pills | 55.02€ 52.40€ | |
| Kamagra | 100mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Viagra Generic | 100mg | 270 + 10 Pills | 270.47€ 257.59€ | |
| Kamagra Polo | 100mg | 20 Pills | 83.56€ 79.58€ | |
| Viagra Generic | 50mg | 270 + 8 Pills | 198.48€ 189.03€ | |
| Viagra Generic | 150mg | 180 + 10 Pills | 236.46€ 225.20€ | |
| Viagra Generic | 200mg | 360 + 10 Pills | 481.98€ 459.03€ |
[60][61] The drug was patented in 1996, approved for use in erectile dysfunction by the FDA on 27 March 1998, becoming the
- Sildenafil 5mg is sometimes prescribed for off-label uses.
- The medication should not be mixed with certain medications like nitrates.
- Purchase only from licensed pharmacies to ensure quality.
- Be aware of potential side effects like headaches and flushing.
- Sildenafil 5mg has a rapid onset of action within 30-60 minutes.
- People with certain health conditions should seek medical advice first.
- The drug is not an aphrodisiac and requires sexual stimulation.
- Sildenafil 5mg tablets are usually small and easy to swallow.
- Check the expiration date before taking the medication.
- Avoid alcohol consumption when using sildenafil for safety.
- Sildenafil 5mg may be used in a combination therapy.
- Read all included patient information leaflet thoroughly.
first oral treatment approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year.
About the Company
[33] The reasons behind such use include the belief that the drug increases libido, improves sexual performance,[33] or permanently increases penis size. [34] Studies on the effects of sildenafil when used recreationally are limited, but suggest it has little effect when used by those who do not have erectile dysfunction. In one study, a 25 mg dose was shown to cause no significant change in erectile quality, but did reduce the postejaculatory refractory time. [35] This study also noted a significant placebo effect in the control group. Unprescribed recreational use of sildenafil and other PDE5 inhibitors is noted as particularly high among users of illegal drugs.
Effective treatments, trusted by over 500,000 men
[36] Sildenafil is sometimes used to counteract the effects of other substances, often illicit. [33] Some users mix it with methylenedioxymethamphetamine (MDMA, ecstasy), other stimulants, or opiates in an attempt to compensate for the common side effect of erectile dysfunction, a combination known as "sextasy", "rockin' and rollin'", "hammerheading", or "trail mix". [33] Mixing it with amyl nitrite, another vasodilator, is particularly dangerous and potentially fatal. The 2007 Ig Nobel Prize in aviation went to Patricia V. Agostino, Santiago A. [62] It soon became a great success: annual sales of Viagra peaked in 2008 at US$1.934 billion.
| Retailer | Website | Price per Pack | Shipping Countries | Customer Ratings |
|---|---|---|---|---|
| OnlinePharma | www.onlinepharma.com | $10 | Global | 4.5/5 |
| MedsDirect | www.medsdirect.com | $8 | USA, UK | 4.2/5 |
| QuickMeds | www.quickmeds.com | $9 | US, CA | 4.6/5 |
| DiscountMeds | www.discountmeds.com | $7 | Global | 4.3/5 |
In the US, even though sildenafil is available only by prescription from a doctor, it was advertised directly to consumers on TV (famously being endorsed by former United States Senator Bob Dole and football star Pelé).
Alternatives to Sildenafil
Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. [4] In October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours.
Should I buy Sildenafil or Generic Viagra Online?
[4] Other drugs that interfere with the metabolism of sildenafil include erythromycin and cimetidine, both of which can also lead to prolonged plasma half-life levels. The use of sildenafil and an α1 blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Concomitant use of nitric oxide donors, organic nitrites and nitrates,[30] such as: nitroglycerinisosorbide mononitrateisosorbide dinitratesodium nitroprussidealkyl nitrites (commonly known as "poppers") Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors. Sildenafil's popularity with young adults has increased over the years. [32] Sildenafil's brand name, Viagra, is widely recognized in popular culture, and the drug's association with treating erectile dysfunction has led to its recreational use. Numerous sites on the Internet offer Viagra for sale after an "online consultation", often a simple web questionnaire.
Is It Safe to Buy Sildenafil Online? Checklist
Plano, and Diego A. Golombek of Universidad Nacional de Quilmes, Argentina, for their discovery that sildenafil helps treat jet lag recovery in hamsters. Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles. In turn, they believe it will enhance their performances. Acetildenafil and other synthetic structural analogs of sildenafil which are PDE5 inhibitors have been found as adulterants in a number of "herbal" aphrodisiac products sold over-the-counter.
Serious but Uncommon
[41] These analogs have not undergone any of the rigorous testing that drugs like sildenafil have passed, and thus have unknown side-effect profiles. [42] Some attempts have been made to ban these drugs, but progress has been slow so far, as, even in those jurisdictions that have laws targeting designer drugs, the laws are drafted to ban analogs of illegal drugs of abuse, rather than analogs of prescription medicines. However, at least one court case has resulted in a product being taken off the market. The US Food and Drug Administration (FDA) has banned numerous products claiming to be Eurycoma longifolia that, in fact, contain only analogs of sildenafil. [44][45][46] Sellers of such fake herbals typically respond by just changing the names of their products. Viagra and other products for sexual dysfunction, termed sexuopharmaceuticals, proliferated new types of specialised marketing for such products.
| Brand Name | Manufacturer | Dosage | Form | Packaging |
|---|---|---|---|---|
| Sildenafil Basic | PharmaCorp Ltd. | 5 mg | Tablets | Blister pack (30) |
| EzSildenafil | MedsPlus Inc. | 5 mg | Tablets | Bottle (60) |
| Pure Sildenafil | HealthPharma | 5 mg | Oral Tabs | Pack of 90 |
| QuickRelease | FastMed Ltd. | 5 mg | Tablets | Blister (20) |
[66] Viagra and similar prescription pharmaceuticals were promoted by images in media to the extent of becoming a cultural icon, at the time a relatively new
CVS PHARMACY
Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose). If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third. When taken orally, sildenafil for erectile dysfunction results in an average time to onset of erections of 27 minutes (ranging from 12 to 70 minutes). Sublingual use of sildenafil for erectile dysfunction results in an average onset of action of 15 minutes and lasting for an average of 40 minutes. The preparation steps sildenafil citrate tablets 150 mg for synthesis of sildenafil are:[54] Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate Hydrolysis with aqueous sodium hydroxide (NaOH) to free acid Carboxamide formation with refluxing thionyl chloride/NH4OH Reduction of nitro group to amino group Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists led by Simon Campbell[55] working at Pfizer's Sandwich, Kent, research facility in England. phenomenon known to be permitted only in the United States and New Zealand and which is believed to have significantly contributed to norms regarding male sexuality. [67] One author notes that although the effect of Viagra is only limited to penile blood vessels, advertisements routinely use imagery
Online Sildenafil Prescription
Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra). Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4 (major route), but also by CYP2C9 (minor route) hepatic isoenzymes. The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further. This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil. Thus, the metabolite is responsible for about 20% of sildenafil's action. of couples hugging, smiling and dancing, with the author claiming that pharmaceutical companies were deceptive in the use of such advertisements.
- Sildenafil 5mg is a popular choice for initial trial.
- It’s important to follow the prescribed schedule.
- Online purchase requires caution and research.
- The medication’s effects can last several hours.
- Keep track of dosages and any side effects.
- Sildenafil 5mg is suitable for men with mild to moderate ED.
- Avoid taking more than the recommended dose.
- Pharmacist consultation can help determine the right dose.
- Sildenafil can be used with care in approved health conditions.
- The medication should be stored safely away from children.
- Check for compatibility with existing health conditions.
- Ensure purchase from licensed, reputable sources.
In 2000, Viagra sales accounted for 92% of the global market for prescribed erectile dysfunction pills.
- Sildenafil 5mg is a lower dose used for specific erectile dysfunction treatments.
- It is available for sale online through licensed pharmacies.
- Always consult a healthcare provider before starting sildenafil.
- Sildenafil 5mg may have fewer side effects than higher doses.
- The medication works by increasing blood flow to the penis.
- It’s important to follow the prescribed dosage for safety.
- Sildenafil 5mg can be used for pulmonary hypertension under medical advice.
- The drug’s effects typically last up to 4-6 hours.
- Price varies depending on the supplier and quantity purchased.
- Generic sildenafil offers a cost-effective alternative.
- Look for reputable sellers to avoid counterfeit products.
- Store sildenafil 5mg in a cool, dry place away from children.