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Tell your healthcare provider if you have any side effect that bothers you or does not go away.

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Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, which breaks down cyclic GMP and enhances nitric oxide (NO) -mediated smooth muscle relaxation. In erectile dysfunction (ED), this increases blood flow to penile tissue, facilitating an erection. In pulmonary arterial hypertension (PAH), it dilates pulmonary vessels by the same mechanism, reducing pulmonary blood pressure and improving exercise capacity. Sildenafil first gained FDA approval on March 27, 1998. Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers".

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Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas). The most common side effects of sildenafil tablets for ED are: Abnormal vision, such as changes in color vision (such as having a blue color tinge) andblurred vision The most common side effects of sildenafil oral film for ED are: Abnormal vision, such as changes in color and blurred vision The most common side effects of sildenafil tablets/ oral suspension, and injection for PAH are: Sildenafil can cause the following serious side effects. If you have an erection that lasts more than 4 hours, get medical help right away. These are not all of the possible side effects of sildenafil. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Have allergies to sildenafil, Viagra, Revatio, Vybrique, or any of the ingredients in the sildenafil formulation you are taking Take other medicines for pulmonary arterial hypertension, such as riociguat (Adempas) Take other medicines for pulmonary arterial hypertension, such as riociguat (Adempas) Take other medicines that lower your blood pressure, such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs that also contain nitrates, such as "poppers".

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To make sure sildenafil is safe for you, tell your healthcare provider about all your medical conditions, including if you have: Or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve, or heart failure Had heart surgery within the last 6 months Low blood pressure, or high blood pressure that is not controlled A physical deformity of the penis (such as Peyronie's disease) Been told you should not have sexual intercourse for health reasons and you are a male Had an erection that lasted for more than 4 hours Problems with your blood cells, such as sickle cell anemia, multiple myeloma, or leukemia Retinitis pigmentosa, a rare genetic (runs in families) eye disease Ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) Kidney problems or are having kidney dialysis Are pregnant or intending to become pregnant (for patients with PAH) Are breastfeeding or intending to breastfeed (for patients with PAH). Sildenafil for ED is not approved for males <18 years old. Sildenafil is not expected to harm an unborn baby.

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Urologist recommends daily Viagra to prevent impotence. Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P.

Pulmonary hypertension

A. Oral sildenafil in the treatment of erectile dysfunction. The New England Journal of Medicine, 338(20), 1397–1404. A prospective study of the beneficial effects of dose optimization and customized instructions on patient satisfaction with sildenafil citrate (Viagra) for erectile dysfunction. International Journal of Impotence Research, 18(5), 389–394. Tell your doctor if you are pregnant or plan to become pregnant.

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Sildenafil may cause low blood pressure, which may cause you to feel faint or dizzy. Lie down if you feel faint or dizzy. Tell your doctor if you get more short of breath after you start sildenafil. More shortness of breath than usual may be due to your underlying medical condition. Do not take Viagra while also taking Revatio. Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor if they discover they are pregnant. It is not known whether sildenafil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breastfeeding a baby.

• Sildenafil citrate 50mg can be used in combination therapy for ED.
• It is vital to follow your doctor’s exact dose and timing instructions.
• Do not take sildenafil if you have a history of allergic reactions.
• Exercise caution if you experience chest pains while on the medication.
• Keep track of any side effects experienced and report them.
• Avoid physical activity immediately after taking the tablet if feeling dizzy.
• The medication does not protect against STDs; use barrier protection.
• Always inform your healthcare provider of all ongoing treatments and medications.

Women with pulmonary arterial hypertension should not stop taking sildenafil without talking to their doctor.

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Doctors typically start at 50 mg and only increase to 100 mg if needed. Physician-Scientist; Founder, Director, and Chief Executive OfficerXYON: Founder, Director, and CEOEducationDoctorate of Medicine (MD) — University of Cape Town, South Africa — 1991Genetics (PhD) — University of Amsterdam, The Netherlands — 1998Internal Medicine (Postgraduate Fellowship) — University of British Columbia (UBC), Canada — 2001Academic & Clinical AppointmentsClinical Assistant Professor, Division of General Internal Medicine — University of British ColumbiaAssociate Member, Division of Cardiology, Department of Medicine — University of British ColumbiaFaculty — Providence Health Care Heart and Lung Institute B., Ströberg, P., Lee, S. W., Park, N. C., Kim, S.-W., Tseng, L.-J., Collins, S., & Stecher, V. J.

What does SILDENAFIL CITRATE (Generic for REVATIO) look like?

Sildenafil citrate 100 mg starting dose in men with erectile dysfunction in an international, double-blind, placebo-controlled study: Effect on the sexual experience and reducing feelings of anxiety about the next intercourse attempt. The Journal of Sexual Medicine, 6(10), 2826–2835. Sildenafil: A review of its use in erectile dysfunction. Effects of two different dosages of sildenafil on patients with erectile dysfunction. American Journal of Men’s Health, 11(3), 747–757. Take sildenafil oral tablets exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much to take and when to take it. Your healthcare provider may change your dose if needed. You may take sildenafil between 30 minutes to 4 hours before sexual activity if needed. If you take sildenafil after a high-fat meal (such as a cheeseburger and fries), sildenafil may take a little longer to start working.

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Tell all your healthcare providers that you take sildenafil. If you need emergency medical care for a heart problem, it will sildenafil for women be important for your healthcare provider to know when you last took sildenafil. Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during sex. Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease. Sildenafil does not protect you or your partner from getting sexually transmitted diseases, including Human Immunodeficiency Virus (HIV). If you accidentally take too much sildenafil, call your doctor or go to the nearest hospital emergency room right away.

• The 50mg dosage is common but adjustable based on individual response.
• Overdose symptoms include severe dizziness, fainting, or prolonged erection.
• Sildenafil can cause visual disturbances, such as blurred vision.
• Use caution when driving or operating machinery after taking.
• Always check the expiration date on the medication packaging.
• Consult a healthcare professional for any underlying health concerns.
• Avoid using grapefruit or grapefruit juice with sildenafil.
• Notify your doctor if you experience chest pain during use.

Sildenafil can help you have an erection when sexual stimulation occurs.

Guidance Point	Details	Rationale
Take on an empty stomach or light meal	Absorption is faster without heavy food	Should be taken about 30-60 minutes before activity
Do not exceed one tablet in 24 hours	Risk of overdose and side effects	To ensure safe and effective treatment
Avoid alcohol consumption during use	Alcohol can increase side effects	Includes dizziness and hypotension
Seek medical advice if experiencing painful erections or vision changes	To prevent complications	Rare but serious side effects

An erection will not occur just by taking a pill.

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Sublingual sildenafil in the treatment of erectile dysfunction: Faster onset of action with less dose. International Journal of Urology, 11(11), 989–993. Sex, erectile dysfunction, and the heart: A growing problem. Phosphodiesterase‑5 (PDE5) inhibitors in the management of erectile dysfunction. Pharmacy and Therapeutics, 38(7), 407–419.

Does sildenafil interact with other medicines (drug interactions)?

Cardiovascular effects of sildenafil citrate and recommendations for its use. American Journal of Cardiology, 84(5), 11N–17N. Pronunciation: sil-DEN-a-fil Generic name: sildenafil Brand names: Revatio, Viagra, Vybrique Dosage form: tablets (20 mg; 25 mg, 50 mg, 100 mg), injection (10 mg/12.5 mL), oral suspension (10 mg/mL), oral film (25 mg, 50 mg, 75 mg, 100 mg) Drug classes: Agents for pulmonary hypertension, Impotence medications Sildenafil is used to treat erectile dysfunction (ED) in adult men or pulmonary arterial hypertension (PAH) in adults and children, depending on the brand or formulation. Sildenafil tablets (25 mg, 50 mg, 100 mg; Viagra, generic) and sildenafil oral film (25 mg, 50 mg, 75 mg, 100 mg; Vybrique) are used for ED. Sildenafil tablets (20 mg; Revatio, generic), sildenafil oral suspension (Revatio, generic), and sildenafil injection (Revatio, generic) are used for PAH. During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of sildenafil. Take sildenafil oral film (Vybrique) exactly as your healthcare provider tells you to take it.

• The use of sildenafil citrate 50mg is often combined with psychological counseling.
• Alcohol and large meals can delay the medication’s effectiveness.
• Do not use sildenafil if you are pregnant or nursing.
• Patients with severe vision problems should consult their doctor before use.
• Sildenafil may cause flushing, nasal congestion, or diarrhea.
• Discontinuation may be advised if adverse reactions occur.
• Use caution in men over the age of 65, as side effects may increase.
• Always follow the instructions provided by your medical professional.

Your healthcare provider will tell you how much sildenafil to take and when to take it.

Condition	Recommended Value	Rationale	Notes
Temperature	20-25°C (68-77°F)	Preserves stability	Keep away from heat and moisture
Humidity	<60%	Prevents tablet degradation	Use airtight container
Light Exposure	Keep in original container, away from light	Prevents chemical breakdown	Store in a cool, dark place
Shelf Life	2-3 years	Ensures potency	Check expiry date

Take sildenafil by mouth about 1 hour before sexual activity.

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If it is not treated right away, priapism can permanently damage your penis. Sildenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. Sudden vision loss in one or both eyes can be a sign of a serious eye problem called non-arteritic anterior ischemic optic neuropathy (NAION). Stop taking sildenafil and call your healthcare provider right away if you havesudden vision loss in one or both eyes.

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Some people may also have ringing in their ears (tinnitus) or dizziness. If you have these symptoms, stop taking sildenafil and contact a doctor right away. In addition, heart attack, stroke, irregular heartbeats, and death have happened rarely in people taking sildenafil. Most, but not all, of these people had heart problems before taking this medicine. It is not known if sildenafil caused these problems.