Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: randomized, placebo-controlled, phase III study
o London New Drugs Group/London
| Aspect | Details |
|---|---|
| Drug Class | Selective Serotonin Reuptake Inhibitor (SSRI) |
| Mechanism of Action | Increases serotonin levels in the nervous system, delaying ejaculation |
| Half-Life | Approximately 19 hours |
| Metabolism | Liver (via CYP enzymes) |
| Excretion | Primarily in urine |
| Interaction Potential | May interact with other serotonergic drugs |
Medicines Evaluation Review, Dapoxetine for premature ejaculation, November 2013, o eMC
How long does dapoxetine make you last in bed
Depression, stress, relationship issues and performance anxiety can all contribute to premature ejaculation. For some men, oversensitivity of the penis or nerve damage may be factors. PE can occasionally be a symptom of a more serious medical condition, like prostate problems. Priligy is only available with a prescription. It can be prescribed by your GP or online from UK regulated pharmacies like Boots Online Doctor.
Further reading and references
With our team of friendly, expert clinicians just a few clicks away, you can avoid the hassle and embarrassment of a doctor's appointment or a trip to the pharmacy. Just fill out our simple online questionnaire and we can tab dapoxetine 30 mg provide PE treatment if suitable for you without needing to wait or talk to anyone directly. We offer Priligy in two strengths: 30mg and 60mg. One of our team can help you with which dose is suitable for you. Priligy can be an effective treatment for men aged between 18-64 years old who've had troublesome PE symptoms in the majority of sexual encounters within the last 6 months. Summary of Product Characteristics, Accessed 07/08/2019.
- Economic burden of PE includes impact on quality of life.
- Dapoxetine can be cost-effective compared to no treatment or therapy alone.
- Adherence improved by clear instructions on timing of intake.
- Missed opportunity: if taken too late, may not be effective.
- Food does not significantly affect absorption; can be taken with/without.
- Potential for mild withdrawal-like symptoms if used very frequently.
- No established benefit for other sexual dysfunctions.
- Research continues on new formulations or delivery methods.
o NICE premature ejaculation:Dapoxetine,Evidence
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Priligy Generic Dapoxetine | 60mg | 30 + 6 Pills | 106.65€ 101.57€ | |
| Priligy Generic Dapoxetine | 60mg | 180 + 10 Pills | 494.76€ 471.20€ | |
| Levitra Generic | 20mg | 10 Pills | 31.49€ 29.99€ | |
| Cialis Original | 20mg | 92 + 4 Pills | 377.99€ 359.99€ | |
| Priligy Generic Dapoxetine | 60mg | 20 + 4 Pills | 77.31€ 73.63€ | |
| Priligy Generic Dapoxetine | 60mg | 90 + 10 Pills | 265.64€ 252.99€ | |
| Cialis Black | 80mg | 90 + 6 Pills | 207.88€ 197.98€ | |
| Kamagra | 100mg | 180 + 6 Pills | 436.79€ 415.99€ | |
| Priligy Generic Dapoxetine | 60mg | 120 + 10 Pills | 341.26€ 325.01€ | |
| Priligy Generic Dapoxetine | 60mg | 60 + 8 Pills | 183.06€ 174.34€ | |
| Priligy Generic Dapoxetine | 60mg | 10 Pills | 47.63€ 45.36€ | |
| Tadalista Super Active | 20mg | 10 Pills | 55.64€ 52.99€ |
Summary [ESNM40] Published date:
What are the side effects of dapoxetine (Priligy)?
Dapoxetine belongs to a group of medicines called selective serotonin reuptake inhibitors (SSRIs). These work by boosting the levels of serotonin in the body, causing a delayed reaction in the areas of the brain that trigger ejaculation. Take one Priligy tablet 1-3 hours before sexual activity, with or without food, with plenty of water. Never take more than one tablet within 24 hours and do not consume alcohol when you use Priligy. Priligy should not be used on a continuous daily basis.
Common side effects of Dapoxetine
Priligy may not work for you the first time you take it. You may need to try the product four separate times to see if it has an effect on you. If it doesn't work after trying it four times, let us know and we can suggest an alternative treatment. Priligy comes in two strengths: 30mg and 60mg. The usual dose is 30mg and this is what we would prescribe for anyone first using Priligy. May 2014 With thanks and acknowledgement to Hertfordshire,
| Study/Source | Efficacy Rate | Satisfaction Level | Notes |
|---|---|---|---|
| Clinical Trial (2022) | 70-80% | High | Significant improvement in ejaculation latency |
| Patient Surveys (2023) | 75% | Very satisfied | Many report improved sexual confidence |
| Meta-Analysis (2021) | 65-85% | Varies | Effectiveness depends on dosage and severity of PE |
| Long-Term Use Reports (2024) | Maintains benefit | Consistent | Most users report sustained effect over time |
Bedfordshire and Luton Commissioning Support 1.1 Harmonisation of
What are the most common side effects of Priligy?
The primary endpoint was the mean time from penetration to ejaculation, the intravaginal ejaculatory latency time (IELT), measured by a partner-operated stopwatch. The pooled mean IELT at 12 weeks was greater than the baseline value in all three groups. Both doses of dapoxetine also produced greater improvements than placebo in subject and partner reported secondary outcomes, including ejaculation-related interpersonal difficulty, personal distress and satisfaction with sexual intercourse. According to sub- group analysis of two trials, response to treatment may be limited among men with mild erectile dysfunction. Dapoxetine is more expensive than other available SSRIs No NHS cost-effectiveness analysis is available.
Priligy side effects
Unclear whether the benefits of dapoxetine are sufficiently clinically important to warrant the additional cost. The needs of the population appear to be low as there are other available treatments which may be used, albeit in an off- label manner. PE is primarily a symptomatic disorder with no known clinical sequelae or complications and therefore may not be regarded as a priority for NHS funding. The needs of the community are considered moderate. The use of dapoxetine instead of less costly off label SSRIs or local anaesthetics could create a cost pressure which may have an impact on the local health economies which already have to identify savings. Hertfordshire Medicines Management Committee (HMMC) guidance and West
Comment in
Priligy should not be taken alongside other SSRI antidepressant medicines — e.g. We can also prescribe Paroxetine tablets to help treat PE, which is another SSRI that works in a similar way to Priligy. Alternatively, EMLA cream is a treatment that contains a local anaesthetic, which decreases sensation in the penis and can therefore delay ejaculation. Counselling can help some men to explore any underlying psychological causes or relationship anxieties that may be contributing to premature ejaculation. Other 'self-help' techniques you can try are: Masturbating 1 to 2 hours before having sex Using a thick condom to help decrease sensation Taking a deep breath to briefly shut down the ejaculatory reflex Distracting yourself by thinking about something else Trying the 'squeeze' technique—squeezing the end of the penis where the glans joins the shaft for several seconds until the urge to orgasm passes Premature ejaculation is when you feel as though you have an inability to control ejaculation and you ejaculate earlier than you would like.
Phosphodiesterase type 5 inhibitors
This often means when you have sex, you can't continue long enough before ejaculating to satisfy both yourself and your partner. It's a common ejaculation problem and affects many men at some point in their lives. PE is not the same as erectile dysfunction (ED), where you may struggle to get or maintain an erection hard enough for sex. If you are experiencing both PE and ED, we recommend that you treat ED symptoms first as this can actually improve PE symptoms also. PE is a complex issue that can be caused by both psychological and physical factors. Essex Medicines Optimisation Programme
- Combining dapoxetine with recreational drugs can be dangerous and is not recommended.
- Dapoxetine can improve quality of life in men with PE.
- Always consult a healthcare provider before starting or stopping medication.
- Maintain open communication with your partner about treatment options.
- Lifestyle adjustments, like reducing stress, can complement medication treatment.
- Regular health screenings are advised during dapoxetine therapy.
Board (WEMOPB) guidance updates
When Dapoxetine May Be Prescribed
Inclusion criteria were restrictive and patients outside the trial population are likely to seek treatment. The most common adverse effects reported are nausea (11.0% and 22.2% in 30 mg and 60 mg prn dapoxetine groups, respectively), dizziness (5.8% and 10.9%), headache (5.6% and 8.8%), diarrhoea (3.5% and 6.9%), insomnia (2.1% and 3.9%) and fatigue (2.0% and 4.1%). Approximately 0.5% dapoxetine-exposed subjects in trials experienced syncope. Some subjects fell and sustained minor injuries. An orthostatic test should be performed and a careful history taken before initiating therapy.
Full Text Sources
Daily use is not recommended as it was associated with withdrawal effects in clinical trials · Dapoxetine is significantly more costly than alternative products used off-label for premature ejaculation. · There is no information on cost effectiveness of dapoxetine. · IELT may not fully reflect patient perceived benefit of treatment. Among men with moderate-to-severe PE, dapoxetine has been shown to increase the time from penetration to ejaculation to a greater extent than placebo. In four similar trials lasting 12 or 24 weeks, a total of 4,843 men with PE who broadly met the licensing criteria were randomised to on-demand use of dapoxetine 30 mg or 60 mg or matching placebo, one to three hours before anticipated sexual activity. include: • Rebadging with HWE ICB and removal
| Side Effect | Frequency | Severity | Management Tips |
|---|---|---|---|
| Nausea | Common | Mild to moderate | Take with food, follow dose instructions |
| Dizziness | Common | Mild | Avoid driving after taking |
| Insomnia | Occasional | Mild | Use earlier in the day if sleep disturbances occur |
| Sudden Drop in Blood Pressure | Rare | Moderate | Monitor BP if prone to hypertension |
| Serotonin Syndrome | Very Rare | Severe | Discontinue and seek medical attention if symptoms occur |
of Herts CCG headers The recommendation is based
Medicine Leaflet Review Manager – Contractor, Pharmacist
It cannot be taken by men who have heart conditions, blood clotting issues, a history of severe mental health problems, or who are taking certain medicines. This is because more severe side effects can occur. You must tell us about any medical issues or medicines you are taking in your questionnaire so we can assess whether Priligy is suitable and safe for you. What it is Short acting selective serotonin reuptake inhibitor (SSRI) Indication Treatment of premature ejaculation (PE) in adult men aged 18 to 64 years. Recommendation:NOT RECOMMENDED for prescribing in primary or secondary care.
In this article:
Dapoxetine is a short acting SSRI licensed for the treatment of premature ejaculation in men aged 18-64 years who meet the following criteria: o An intravaginal ejaculatory latency time (IELT) of less than two minutes; and o Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes; and o Marked personal distress or interpersonal difficulty as a consequence of PE; and o A history of premature ejaculation in the majority of intercourse attempts over the prior 6 months. Dapoxetine dose is 30-60mg orally as required but maximum once every 24 hours. Four short term published trials in nearly 5000 men showed increased time from penetration to ejaculation (IELT) in dapoxetine groups compared with placebo. Trials were not designed to compare the relative efficacy of the 2 doses of dapoxetine. There is no efficacy and safety data beyond 24 weeks and no active comparator arm was used in trials. upon the evidence available at the time of publication.
- Dapoxetine has been shown to significantly increase ejaculatory latency time.
- It is not intended to treat all aspects of sexual dysfunction.
- Use of dapoxetine may require dose adjustments based on side effects.
- The medication should be stored safely out of children's reach.
- Monitoring response and side effects enhances safe use of dapoxetine.
- Dapoxetine should be used only as part of a broader treatment plan.
This recommendation will be reviewed upon request
- Dapoxetine's impact on libido is generally minimal, focusing on ejaculation control.
- Use of dapoxetine should be part of an overall sexual health plan.
- Adherence to prescribed doses maximizes benefits and minimizes risks.
- Side effects usually resolve within a few hours or days.
- Avoid driving or operating heavy machinery after taking dapoxetine if drowsiness occurs.
- Regular discussions with your healthcare provider improve treatment outcomes.
in the light of new evidence becoming available.
Article history
If, after trying four separate times, this hasn't been effective for you, contact us through your online patient record and we might be able to offer you the 60mg dose to try. Priligy (dapoxetine) is up to 80% effective in the treatment of premature ejaculation. This means up to 8 out of 10 men will notice an improvement in symptoms. As with all medicines, there's the possibility of experiencing side effects when taking Priligy. Please read the treatment plan we send if we prescribe Priligy and the Patient Information Leaflet for full details on possible side effects before taking this medicine.
Medication interactions
The most common side effects people experience with Priligy are nausea, dizziness, headache, fainting and diarrhoea. Please contact us through your online patient record if you're concerned about any side effects you experience. Do not take Priligy alongside oral ED medicines, as this can cause your blood pressure to drop resulting in dizziness or feeling faint especially if you stand up. You should leave at least 24 hours between taking Priligy and taking Viagra (Sildenafil), Spedra (Avanafil) or Levitra (Vardenafil); and if taking Priligy and Cialis (Tadalafil) leave at least 48 hours between taking each medicine. Make sure you are in a position to be able to sit or lie down if you do feel faint or dizzy and do not drive, operate machinery or undertake hazardous activities until the feeling of faintness has completely gone away.