Dapoxetine 30mg Tablet
Dapoxetine Hydrochloride is a selective serotonin reuptake inhibitor medicine which has specially been developed for the treatment of premature ejaculation.
- Post-marketing surveillance continues for rare side effects.
- Priapism is a rare but serious urological emergency.
- Patients experiencing prolonged erection must seek help.
- Syncope can lead to falls and injury.
- Taking the first dose in a safe setting is advised.
- Blood pressure monitoring may be recommended.
- It can cause dose-dependent increases in heart rate.
- Patients with uncontrolled hypertension should avoid it.
- It is not studied in men with significant cardiovascular disease.
- Sexual activity itself poses cardiac risk for some.
- A pre-treatment cardiovascular assessment may be needed.
- The decision involves balancing cardiac and sexual health.
It increases the time it takes to ejaculate and can improve the control over the ejaculation.
| Contraindication | Reason | Notes |
|---|---|---|
| Concurrent MAOI use | Risk of serotonin syndrome | Must wait at least 14 days after MAOI stop |
| Liver impairment | Slower drug metabolism | Consult healthcare provider |
| Hypersensitivity | Allergic reactions possible | Discontinue if allergic response occurs |
It starts to work very quickly, so it is taken when you anticipate having sex, rather than every day.
- The medication should be part of a treatment plan.
- The plan includes follow-up, dose adjustment, and support.
- Treatment success is not solely defined by time.
- Improved perceived control and satisfaction are key.
- Partners may be included in counseling sessions.
- Communication skills are often addressed.
- Sensate focus exercises may be recommended.
- The drug can provide a "window of opportunity" for therapy.
- Some men may eventually discontinue medication.
- Others may require long-term intermittent use.
- There is no defined maximum duration of use.
- Annual review of continued need is prudent.
You have to take it 1 to 3 hours before you have sex.
Brief Description
Dapoxetine is contraindicated in patients with moderate and severe hepatic impairment. Pregnancy Dapoxetine is pregnancy category C. Dapoxetine is not indicated for use by women. There are no adequate and well-controlled studies of Dapoxetine in pregnant women. Lactation Dapoxetine is not indicated for use by women.
Neurocognitive safety
It is not known if either Dapoxetine or its metabolites are excreted in human breast milk. General Dapoxetine is only indicated in men with premature ejaculation. Safety has not been established and there are no data on the ejaculation-delaying effects in men without premature ejaculation. Use with recreational drugs Patients should be advised not to use Dapoxetine in combination with recreational drugs with serotonergic activity such as ketamine, methylenedioxymethamphetamine (MOMA) and lysergic acid diethylamide (LSD) because these may lead to potentially serious reactions if combined with Dapoxetine. Syncope The occurrence of syncope and possibly prodromal symptoms appears dose dependent as demonstrated by higher incidence among patients treated with doses higher than 60 mg, the recommended maximum daily dose.
If you forget to take PRILIGY
Orthostatic hypotension An orthostatic test should be performed before initiating therapy. In case of a history of documented or suspected orthostatic reaction, treatment with Dapoxetine should be avoided. Warning Combining alcohol with Dapoxetine may increase alcohol related neurocognitive effects and may also enhance neurocardiogenic adverse events such as syncope, thereby increasing the risk of accidental injury; therefore, patients should be advised to avoid alcohol while taking Dapoxetine. The most common reported side effects are loss of consciousness, orthstatic hypotension, headache, dizziness, nausea, diarrhoea, insomnia and fatigue. Dapoxetine is contraindicated in patients with known hypersensitivity to Dapoxetine or to any of the excipients. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Poxet Dosage The dosage of Poxet tablets (Generic Dapoxetine Hydrochloride Tablets) for adult men (aged 18 to 64 years) is given below: The recommended starting dose for all patients is 30 mg, taken as needed approximately 1 to 3 hours prior to sexual activity.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Priligy Generic Dapoxetine | 60mg | 180 + 10 Pills | 494.76€ 471.20€ | |
| Priligy Generic Dapoxetine | 60mg | 30 + 6 Pills | 106.65€ 101.57€ | |
| Priligy Generic Dapoxetine | 60mg | 20 + 4 Pills | 77.31€ 73.63€ | |
| Viagra Soft Tabs | 100mg | 120 + 8 Pills | 232.21€ 221.15€ | |
| Priligy Generic Dapoxetine | 60mg | 90 + 10 Pills | 265.64€ 252.99€ | |
| Priligy Generic Dapoxetine | 60mg | 60 + 8 Pills | 183.06€ 174.34€ | |
| Priligy Generic Dapoxetine | 60mg | 10 Pills | 47.63€ 45.36€ | |
| Priligy Generic Dapoxetine | 60mg | 120 + 10 Pills | 341.26€ 325.01€ | |
| Viagra Generic | 25mg | 270 + 8 Pills | 184.26€ 175.49€ | |
| Viagra Super Active | 100mg | 90 + 10 Pills | 165.61€ 157.72€ |
Treatment with Poxet (Generic Dapoxetine Hydrochloride tablets) should not be started with the 60 mg dose. Poxet is not intended for continuous daily use.
3. What if I am taking other medicines?
Secondary Premature Ejaculation The condition has developed after the man used to have satisfying sex without ejaculatory problems. — Various treatment options for premature ejaculation — Easy-to-understand information about premature ejaculation at the Mayo Clinic web site “Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials” The Lancet 2006; 368:929-937 You will need to subscribe to the Lancet to view the article online Written by: Christian Nordqvist Editor: Medical News Today © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Poxet (Generic Dapoxetine Hydrochloride Tablets) is used to treat premature ejaculation (PE) in men 18 to 64 years of age, who have persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes and marked personal distress or interpersonal difficulty as a consequence of PE and poor control over ejaculation. This can cause problems for the man and may cause problems in sexual relationships. Dapoxetine HCl belongs to a group of medications called 'selective serotonin reuptake inhibitors' (SSRIs). This medicine increases the time it takes to ejaculate and can improve the control over the ejaculation, which in turn may reduce the frustration or worry about fast ejaculation. Poxet should be taken only when sexual activity is anticipated.
Dapoxetine 30mg Details
You can read about this in the journal dapoxetine spain The Lancet. The research team examined the results of two trials, totalling 2,614 men. All the men had from moderate to severe premature ejaculation – on average, the men were ejaculating within one minute of penetration. Half of them were randomly selected to receive Dapoxetine while the other half received a placebo. Both groups had to take their medication from 1 to 3 hours before sexual intercourse.
Depression and anxiety
After three months, the men taking a 30-milligram dose of dapoxetine took an average 2.78 minutes to ejaculate after penetration, those on a 60-milligram dose took 3.32 minutes. The placebo group averaged 1.75 minutes (after three months). Dapoxetine was rejected by the FDA last year. In lay terms it means ‘coming too quickly’ (for a man). The man ejaculates sooner than he or his partner would like.
Looking after your medicine
It is common for this to happen now and again. It is seen as a problem for many men and some of their partners if this happens regularly. It is the most common male sexual dysfuntion – estimated to affect about 20% of males in the USA aged 18-59. The problem is thought to be psychological. Primary Premature Ejaculation The man has experienced premature ejaculation throughout his sexually active life. Poxet must not be taken more frequently than once every 24 hours.
Safety Assessments
© Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Active Ingredient The active ingredient contained in Poxet tablets is Dapoxetine Hydrochloride. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Chemical Structure The structure of Dapoxetine Hydrochloride is given below: © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Poxet Tablets are manufactured by Sunrise Remedies Private Limited, India in the strengths of of 30 mg, 60 mg and 90 mg. (Website: URL: © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Dapoxetine Hydrochloride Tablets – Brand Names Dapoxetine Hydrochloride tablets are available under various Drug trade names that include Priligy, Poxet, Dapox, Dasutra, Duralast, Ejalong, Kutub and Sustinex. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Uses of Poxet Tablets Poxet (Generic Dapoxetine Hydrochloride Tablets) is a treatment for men 18 to 64 years old with frequent premature ejaculation (PE), which troubles the man and affects the relationship with his sexual partner. PE is a common medical condition in which ejaculation happens with minimal sexual stimulation before, on, or shortly after penetration, and before the man wishes it. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Poxet Dosage The dosage of Poxet tablets (Generic Dapoxetine Hydrochloride Tablets) for adult men (aged 18 to 64 years) is given below: If the individual response to 30 mg is insufficient and the patient has not experienced moderate or severe adverse reactions or prodromal symptoms suggestive of syncope, the dose may be increased to a maximum recommended dose of 60 mg taken as needed approximately 1 to 3 hours prior to sexual activity. The incidence and severity of adverse events is higher with the 60 mg dose.
- Discontinuation rates in studies are often due to side effects.
- Nausea is the most common reason for stopping.
- Taking the tablet with a light snack may reduce nausea.
- Dizziness can be mitigated by rising slowly from sitting.
- Headaches may be managed with simple analgesics.
- If side effects are intolerable, the drug should be stopped.
- A lower dose is not available below 30mg.
- Therefore, discontinuation is the only option if 30mg is not tolerated.
- Most side effects are mild to moderate and transient.
- They often diminish with continued use.
- However, continued use does not mean daily use.
- Tolerance to the therapeutic effect does not develop.
If the patient experienced orthostatic reactions on the starting dose, no dose escalation to 60 mg should be performed.
| Aspect | Description | Notes |
|---|---|---|
| Generic Name | Dapoxetine | Also known as Priligy |
| Dosage | 30 mg per tablet | Usually taken 1-3 hours before activity |
| Formulation | Oral tablet | Available in blister packs |
| Manufacturer | Multiple pharmaceutical companies | Not brand-specific |
© Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Contraindications Poxet tablets are contraindicated in persons with a hypersensitivity (allergy) to Dapoxetine Hydrochloride or any of the other ingredients of this medicine.
Dosage and Strengths
It is also contraindicated in patients with heart failure, conduction abnormalities (second or third degree AV block or sick sinus syndrome) not treated with a permanent pacemaker, significant ischemic heart disease or significant valvular disease. It may also interact with SSRls, MAO ls, thioridazine, serotonin-norepinephrine reuptake inhibitors (SNRls}, tricyclic antidepressants (TCAs} and other serotonergic medicinal/herbal products. There were no unexpected events of overdose is reported with daily doses up to 240 mg (two 120 mg doses given 3 hours apart). In general, symptoms of overdose with SSRls include serotonin-mediated adverse reactions such as somnolence, gastrointestinal disturbances such as nausea and vomiting, tachycardia, tremor, agitation and dizziness. In cases of overdose, standard supportive measures should be adopted as required.
Reporting side effects
Due to high protein binding and large volume of distribution of Dapoxetine, forced diuresis, dialysis, hemoperfusion and exchange transfusion are unlikely to be of benefit. No specific antidotes for Dapoxetine are known. Store in a cool & dry place protected from light. Keep away from the reach of children. Dapoxetine, a new antidepressant, has been found to be safe and effective for the treatment of premature ejaculation, according to two major clinical trials.
How much to take
Dapoxetin is a short-acting selective serotonin reuptake inhibitor (SSRI). It is not uncommon for SSRIs to be used off-label for premature ejaculation. Experts doubt it will be approved by the FDA shortly because SSRIs come with undesirable side-effects after long-term use, such as psychiatric problems, dermatological reactions, increase in body weight, lower sex-drive, nausea, headache, upset stomach and weakness. Dr. Jon Pryor, head researcher, University of Minnesota, said that Dapoxetine lengthened ejaculation time and also gave patients more control over ejaculation. Poxet tablets are also contraindicated in patients with significant pathological cardiac conditions, for concomitant treatment with monoamine oxidase inhibitors (MAOIs), or within fourteen days of discontinuing treatment with an MAOI, concomitant treatment with Thioridazine, or within 14 days of discontinuing treatment with Thioridazine, concomitant treatment with serotonin reuptake inhibitors , concomitant treatment with potent CYP3A4 inhibitors such as Ketoconazole, Itraconazole, Ritonavir, Saquinavir, Telithromycin, Nefazodone, Nelfinavir, Atazanavir, etc.
| Parameter | Value | Details |
|---|---|---|
| Absorption | Rapid | Peak plasma at 1-2 hours |
| Bioavailability | Approximately 64% | Oral administration |
| Half-life | 12-13 hours | Duration of action |
| Metabolism | Liver via CYP3A4 enzymes | Hepatic pathways |
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