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Vardenafil prevents an enzyme called phosphodiesterase-5 (PDE-5) from destroying cGMP so that cGMP persists longer.
| Side Effect | Frequency | Severity | Management |
|---|---|---|---|
| Headache | Common | Mild | Over-the-counter analgesics |
| Flushing | Common | Mild | Cooling measures |
| Nasal congestion | Less common | Mild | Symptomatic relief |
| Dizziness | Less common | Mild | Avoid driving or operating heavy machinery |
The longer cGMP persists, the more prolonged the engorgement of the penis. Vardenafil was approved by the FDA in August 2003. The most common side effects of vardenafil are Vardenafil also may cause chest pain, low blood pressure, blurred vision and changes in color vision, abnormal ejaculation and priapism (painful erection lasting more than 6 hours). Patients should seek immediate medical help if they experience an erection lasting more than 4 hours. Rare cases of sudden loss of hearing have been reported with phosphodiesterase inhibitors such as vardenafil, sometimes associated with ringing in the ears and dizziness.
| Condition | Recommendation | Notes |
|---|---|---|
| Concurrent nitrate therapy | Do not use | Risk of severe hypotension |
| Severe cardiac conditions | Consult healthcare provider | Use with caution |
| Liver impairment | Dose adjustment needed | Due to metabolism via liver |
| Allergic reaction to vardenafil | Discontinue use | Immediate medical attention |
If changes in hearing occur, patients should discontinue their vardenafil and seek immediate medical attention. For most individuals, the recommended dose of vardenafil regular tablets is 10 mg per day taken 60 minutes before intercourse. If there is no response or side effects, the dose may be increased to 20 mg or, if there are side effects, it may be reduced to 5 mg. Individuals 65 years of age or older should begin therapy with 5 mg. Individuals who are taking medications that increase the blood levels of vardenafil should start treatment with 2.5 to 5 mg of vardenafil. Orally disintegrating tablets (ODT) are not interchangeable with regular vardenafil tablets because they are better absorbed and produce higher blood levels than regular tablets. The recommended dosing when using ODT is one tablet 60 minutes before intercourse. Only one tablet should be used per day. It should be placed on the tongue until it disintegrates and should not be swallowed with water. Ultrafine Wildfire Smoke Particles May Pose Serious Health Risks High Fitness Doesn't Raise A-fib Risk in Young Men Weight Loss Program Helps Women Battling Breast Cancer Cheaper, Alternative Health Plans Are Having a Moment Antibiotics Won't Help Ease Asthma-Linked Wheezing in Kids The breakdown and elimination of vardenafil from the body is inhibited by erythromycin, clarithromycin (Biaxin), ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan), ritonavir (Norvir), atazanavir (Reyataz), grapefruit juice. Therefore, these drugs increase the concentration of vardenafil in the blood and should not be combined with vardenafil.
| Study | Percentage of Patients Reporting Improvement | Sample Size | Notes |
|---|---|---|---|
| Clinical Trial A | 75% | 150 | Overall effectiveness high |
| Clinical Trial B | 80% | 200 | Similar results across studies |
| Real-world data | 70-85% | Varies | Effectiveness observed in practice |
Vardenafil reduces the concentration of ritonavir and indinavir and may reduce the effect these drugs. Vardenafil increases heart rate and also exaggerates blood fildena 100mg pressure lowering effects of nitrates (for example, nitroglycerine). In patients with chest pain (angina), particularly those who take nitrates,, vardenafil can cause chest pain by increasing heart rate and lowering blood pressure. Therefore, patients with angina should not use vardenafil. Vardenafil also exaggerates the blood pressure lowering effects of alpha-blocking drugs, for example, terazosin (Hytrin), and should not be used by individuals who also use alpha-blockers.
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American Journal of Cardiology, 92(8), 1048-1053. Clinical pharmacology review of vardenafil NDA 21-400. Simultaneous administration of vardenafil and tamsulosin does not cause hypotension. Grapefruit juice-drug interactions: A practical review. Co-administration is possible, but only after the α-blocker dose is stabilized; otherwise, symptomatic hypotension may occur.
Related Disease Conditions
If I am already on tamsulosin, how long should I wait before taking vardenafil? Clinical studies suggest dosing vardenafil at least two hours after tamsulosin minimizes additive blood-pressure effects. Yes; grapefruit compounds inhibit CYP3A4 and can unpredictably raise drug levels, increasing side-effect risk. Even one glass may alter metabolism; consistent, limited intake or complete avoidance is advisable to maintain predictable exposure. Are over-the-counter sexual enhancers safe tadalista super active 20 with vardenafil? Vardenafil also adds to the blood pressure reducing effect of other medications. Vardenafil is not approved for use in women. Vardenafil has not been evaluated in women who are breastfeeding. Tablets: 2.5, 5, 10 and 20 mg. Tablet (orally disintegrating): 10 mg. Vardenafil should be stored at room temperature between 15-30 C (59-86 F).
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Vardenafil (Levitra, Staxyn ODT) is a drug prescribed for the treatment of impotence (erectile dysfunction). Side effects, drug interactions, pregnancy information, dosing, and patient information should be reviewed prior to taking any medication.
Pregnancy & Lactation
Store vardenafil tablets at controlled room temperature, 20-25 °C (68-77 °F), with permissible excursions between 15 °C and 30 °C. Vardenafil for the treatment of erectile dysfunction: A critical review. Phosphodiesterase 5: Structure-function regulation and selectivity. PubChem compound summary for CID 135400189, vardenafil. Risk of death in patients with coronary artery disease taking phosphodiesterase 5 inhibitors.
Pregnancy and breastfeeding
Journal of the American College of Cardiology, 82(12), 1123-1135. Evaluation of vardenafil on cardiac repolarization in healthy men. The American Journal of Cardiology, 93(9), 1378-1383. Pharmacology and drug-interaction effects of phosphodiesterase 5 inhibitors. International Journal of Clinical Practice, 59(9), 1165-1170. Erectile Dysfunction (ED) Causes and TreatmentHaving erection problems? Learn about erectile dysfunction causes and treatments such as drugs.. Healthy Aging: Better Sex After 50It's never too late to improve your sex life. Learn how older adults can overcome common health conditions affecting seniors over.. It's never too late to improve your sex life. Sex Quiz: Love & Relationships FactsRelationships, sex, and love!
- Vardenafil's active ingredient is vardenafil hydrochloride.
- It is often preferred for its rapid onset compared to others.
- It can be used successfully in men with nerve damage.
- Vardenafil may cause temporary visual color changes.
- It is not suitable for individuals with severe heart failure.
- Alcohol can impair the effectiveness of vardenafil.
- Taking it on an empty stomach may improve absorption.
- Avoid driving or operating machinery after taking Vardenafil.
- It is important to follow-up with your healthcare provider regularly.
- Do not double dose if the first dose is ineffective.
- Use the lowest effective dose to minimize side effects.
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Author information
Our team of experts has the answers you're looking for. A clinical pharmacist cannot recommend a specific doctor. Because we are licensed in all 50 states*, we can accept prescriptions from many licensed prescribers if the prescription is written within their scope of practice and with a valid patient-practitioner relationship. Each injectable IV product will have the osmolarity listed on the label located on the vial. Given the vastness and uniqueness of individualized compounded formulations, it is impossible to list every potential compound we offer.
What else should I know about vardenafil?
To inquire if we currently carry or can compound your prescription, please fill out the form located on our Contact page or call us at (877) 562-8577. We source all our medications and active pharmaceutical ingredients from FDA-registered suppliers and manufacturers. Vardenafil is an oral drug that is used to treat impotence, the inability to attain or maintain a penile erection. It has a mechanism of action that is similar to sildenafil (Viagra), and tadalafil (Cialis). Penile erection is caused by the engorgement of the penis with blood. Erectile Dysfunction (Impotence) Quiz: Causes & TreatmentDid you know that certain medical condition may be responsible for ED? Some causes of impotence are medically treatable and..
- Vardenafil dosage adjustments may be needed for older adults.
- It may pose risks in men with low blood pressure.
- Always adhere to the prescribed therapeutic regimen.
- It is not recommended to exceed 20 mg per dose.
- Vardenafil is not intended for use with other ED medications.
- Precise timing of doses ensures efficacy and safety.
- The drug may improve sexual confidence and satisfaction.
- Side effects are usually temporary and dose-related.
- Alcohol and high-fat foods can delay onset of action.
- Avoid using Vardenafil if allergies to it are known.
- Proper hydration can enhance its effectiveness.
Did you know that certain medical condition may be responsible for ED? Picture of PenisThe penis is the male sex organ, reaching its full size during puberty.
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This engorgement occurs when the blood vessels delivering blood to the penis increase in size and increase the delivery of blood to the penis. At the same time, the blood vessels carrying blood away from the penis decrease in size and decrease the removal of blood from the penis. Sexual stimulation that leads to the engorgement and erection causes the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase to produce cyclic guanosine monophosphate (cGMP). The cGMP is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis, respectively. See a picture of the Penis and learn more about the.. The penis is the male sex organ, reaching its full size during puberty.
Medical uses
Many contain undeclared PDE5 analogues or nitrates, posing serious interaction risks; avoid concurrent use. What if I experience dizziness after dosing? Sit or lie down until symptoms pass; if severe or persistent, seek medical attention as this may indicate significant hypotension. No evidence supports physical dependence, but psychological reliance on performance medications can develop, warranting periodic assessment. How effective is vardenafil compared with other PDE5 inhibitors?
Medical Professionals
Trials report 70-80 % successful intercourse attempts versus 50-60 % with placebo, comparable to sildenafil and tadalafil. Macrolides such as clarithromycin inhibit CYP3A4 and can raise vardenafil levels, necessitating dose adjustment. Daily use is not approved; the safety database supports on-demand dosing only, with insufficient data on chronic daily administration. 503A pharmacies compound products for specific patients whose prescriptions are sent by their healthcare provider. 503B outsourcing facilities compound products on a larger scale (bulk amounts) for healthcare providers to have on hand and administer to patients in their offices. Why Do I Keep Losing My Erection?If you keep losing an erection during sex, you are not alone. Erectile dysfunction (ED) is common and occurs for a wide variety of reasons, from psychological to physical. If you keep losing an erection during sex, you are not alone.
What special precautions should I follow?
Ocular side effects of vardenafil: Results of a double-blind study. The Journal of Sexual Medicine, 17(11), 2057-2065. Cardiac safety in clinical trials of PDE5 inhibitors. Cardiology in Review, 13(4), 213-220. Simultaneous administration of vardenafil and tamsulosin in benign prostatic hyperplasia.
Best Practices for Timing Administration:
Optimization of factors affecting vardenafil absorption using β-cyclodextrin. Pharmaceutical Development and Technology, 24(3), 354-364. Korean Journal of Urology, 47(9), 1001-1008. Interactions between grapefruit juice and cardiovascular drugs. American Journal of Cardiovascular Drugs, 4(5), 281-297. Erectile DysfunctionErectile dysfunction (ED, impotence) is the failure to achieve or maintain an erection.