Patient Experiences with Tadalafil for Sexual Wellness
SM Hassan and D Farouk: Clitoral Doppler assessment and data collection. All authors provided their agreement to publish this work. The Ethical Committee of the Urology department approved the research, as well as the Research Ethical Committee (REC) of the Faculty of Medicine, Cairo University (IRB number: N-436–2023, Approval date 10–12-2023). Clinical trial registration was done in February 2022 (ClinicalTrials.gov Identifier: NCT05266651). A written consent was obtained from each participant after a clear and a precise explanation of the study aim, methodology and risks. The authors declare no conflicts of interest.
Author information
Sexual function was assessed using the Female Sexual Function Index (FSFI). Their FGM type was classified on the basis of WHO criteria. Clitoral color Doppler ultrasonography measured peak systolic velocity (PSV), resistance index (RI), and pulsatility index (PI). The primary endpoint was the between-group difference in change in total FSFI score from baseline to 8 weeks. Tadalafil significantly improved total FSFI score compared with placebo (mean change +5.47 vs −0.41; p < 0.001).
Authors and Affiliations
Improvements were observed across all FSFI domains except lubrication. Significant increases in clitoral PSV, RI, and PI were detected in the tadalafil group, whereas no significant changes occurred in the placebo group. Greater benefit was observed in women with type I FGM. Once-daily tadalafil 5 mg for 8 weeks significantly improves sexual function and genital vascular parameters in women with FGM-related FSD, supporting its potential therapeutic role in this population. The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.
Regulatory considerations
Diagnostic and Statistical Manual of Mental Disorders, 4th Ed Diagnostic and Statistical Manual of Mental Disorders, 4th Ed Basson R. Women’s sexual dysfunction: revised and expanded definitions. Basson R. Women’s sexual dysfunction: revised and expanded definitions. Epidemiology and risk factors of sexual dysfunction. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
- Tadalafil may supplement other treatments for female sexual health.
- Its effects on vaginal lubrication are being studied.
- Use in women should be monitored carefully for adverse effects.
- It could provide a new option for women unresponsive to other therapies.
- The drug enhances vascular dilation in female genitalia.
- Long-term safety data in women are lacking.
- Its role in clinical practice remains experimental.
- Dose flexibility allows tailored treatment plans.
- Women interested should seek professional guidance.
Can Low Dose Tadalafil Improve the Sexual Functions in Women with Genital Mutilation?.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Tadalista Super Active | 20mg | 180 + 20 Pills | 521.59€ 496.75€ | |
| Cialis Generic | 20mg | 10 Pills | 31.49€ 29.99€ | |
| Cialis Generic | 60mg | 90 + 6 Pills | 196.67€ 187.30€ | |
| Cialis Generic | 5mg | 30 + 4 Pills | 53.56€ 51.01€ | |
| Cialis Generic | 2.5mg | 30 + 4 Pills | 51.95€ 49.48€ | |
| Cialis Generic | 5mg | 120 + 6 Pills | 132.92€ 126.59€ | |
| Tadalista Super Active | 20mg | 30 + 6 Pills | 128.09€ 121.99€ | |
| Cialis Generic | 40mg | 60 + 6 Pills | 130.98€ 124.74€ | |
| Cialis Generic | 5mg | 60 + 4 Pills | 86.02€ 81.92€ | |
| Cialis Generic | 20mg | 180 + 10 Pills | 254.09€ 241.99€ | |
| Cialis Generic | 60mg | 270 + 10 Pills | 443.96€ 422.82€ | |
| Cialis Generic | 10mg | 180 + 8 Pills | 236.88€ 225.60€ | |
| Tadalista Super Active | 20mg | 60 + 8 Pills | 230.32€ 219.35€ | |
| Cialis Generic | 2.5mg | 360 + 10 Pills | 260.03€ 247.65€ | |
| Cialis Generic | 20mg | 20 Pills | 54.72€ 52.11€ | |
| Cialis Generic | 20mg | 60 + 6 Pills | 117.76€ 112.15€ | |
| Cialis Generic | 20mg | 30 + 4 Pills | 68.05€ 64.81€ |
Some benefits, especially in ability to achieve orgasm, were reported. Men and women who take selective or nonselective serotonin reuptake inhibitors (SRIs) commonly report sexual dysfunction; the main difficulties among women are orgasmic dysfunction and problems with arousal, including lubrication.
Can woman take tadalafil?
493–538. Female sexual dysfunction: classification, pathophysiology, and management. Washington DC: American Psychiatric Association; 2000. p. 493–538.
Comparison with other treatments
Sexual function in women with female genital mutilation. Clinical and preclinical treatment of urologic diseases with phosphodiesterase type 5 inhibitors: an update. Phosphodiesterase type 5 inhibitors for the treatment of female sexual dysfunction: a systematic review and meta-analysis. Ashton A, Weinstein W. Tadalafil reversal of sexual dysfunction caused by serotonin-enhancing medications in women. Studies of selective phosphodiesterase type 5 inhibitors (sildenafil [Viagra], vardenafil [Levitra], and tadalafil [Cialis]) as therapy for women with sexual arousal disorder have produced mixed results. In this multisite trial, funded by sildenafil’s manufacturer, researchers enrolled 98 women (mean age, 37) who had normal sexual function before treatment for depression, were being treated successfully with SRIs (usually fluoxetine, sertraline, or paroxetine; mean treatment time, 28 months), and had substantial s… Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health Dr. Srishti Rastogi is a medical writer and healthcare professional dedicated to high-quality patient education and public health awareness. Leveraging her clinical background, she produces deeply researched, evidence-based content for digital health platforms and medical publications. Dr. Srishti’s unique dual perspective as a clinician and communicator allows her to craft content that builds trust and credibility with readers navigating sensitive health topics. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.
- Tadalafil is sometimes studied for female sexual arousal disorder.
- It may increase blood flow to genital areas in women.
- Tadalafil can help improve sexual satisfaction in women.
- Used off-label, as it’s not officially approved for women.
- Potential side effects include headache and flushing in women.
- Research on tadalafil’s effects on female libido is ongoing.
- Tadalafil might benefit women with sexual arousal issues.
- Dosage for women is not standardized; typically lower doses.
- Used in clinical trials to assess its safety for women.
Unique Aspects of Clinical Trials in Male Sexual Dysfunction Generic name: tadalafil [ ta-DAL-a-fil ] Brand names: Adcirca, Cialis Drug classes: Agents for pulmonary hypertension, Impotence medications Tadalafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Tadalafil under the name of Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate). Another brand of tadalafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Do not take tadalafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Some medicines can cause unwanted or dangerous effects when used with tadalafil. Tell your doctor about all your current medicines, especially riociguat (Adempas).
| Aspect | Observations | References |
|---|---|---|
| Libido Enhancement | Mixed results; some women report improvement | Several small studies |
| Orgasm Frequency | Few studies suggest possible increase | Data limited |
| Sexual Satisfaction | Improved in some clinical trials | Subjective reports |
| Anxiety related to sexual activity | Possible reduction with improved blood flow | Hypotheses under study |
Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.
How should this medicine be used?
Tadalafil 5 mg daily treatment for sexual arousal disorder in type 1 diabetic premenopausal women. All authors would like to thank the patients who participated in sublingual tadalafil this study. No external funding was received for this study. The study was supported by departmental/investigator resources. AM Rammah: Project development, Data Collection, Manuscript writing. Get medical help at once if you have nausea, chest pain, or dizziness during sex. Stop using tadalafil and get emergency medical help if you have sudden vision loss. You should not take tadalafil if you are allergic to it. Taking tadalafil with certain other medicines can cause a sudden and serious decrease in blood pressure. Do not take this medicine if you also use: riociguat (to treat pulmonary arterial hypertension); or riociguat (to treat pulmonary arterial hypertension); or a nitrate drug (for chest pain or heart problems) such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, or recreational drugs such as amyl nitrate or nitrite "poppers".
- Tadalafil's role in female sexual health is promising but unconfirmed.
- It may be used alongside counseling for better outcomes.
- The medication helps enhance blood flow to the clitoris and labia.
- Not recommended as a first-line treatment for women.
- Tadalafil research involves small sample sizes so far.
- Its use in women is increasingly accepted in clinical trials.
- Women should discuss potential risks with healthcare providers.
- It is available in some countries specifically for research use.
- Further evidence needed to recommend widespread use.
a nitrate drug (for chest pain or heart problems) such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, or recreational drugs such as amyl nitrate or nitrite "poppers". Some tadalafil can remain in your bloodstream for 2 or more days after each dose you take (longer if you have liver or kidney disease). To make sure this medicine is safe for you, tell your doctor if you have ever had: angina (chest pain), high or low blood pressure; angina (chest pain), high or low blood pressure; pulmonary hypertension (unless you are taking tadalafil for this); pulmonary hypertension (unless you are taking tadalafil for this); a condition called pulmonary veno-occlusive disease (narrowing of the veins that carry blood from the lungs to the heart); a condition called pulmonary veno-occlusive disease (narrowing of the veins that carry blood from the lungs to the heart); liver or kidney disease (or if you are on dialysis); liver or kidney disease (or if you are on dialysis); vision loss, or retinitis pigmentosa (an inherited condition of the eye); vision loss, or retinitis pigmentosa (an inherited condition of the eye); a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia; a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia; a physical deformity of the penis (such as Peyronie's disease), or an erection lasting longer than 4 hours; a physical deformity of the penis (such as Peyronie's disease), or an erection lasting longer than 4 hours; health problems that make sexual activity unsafe. health problems that make sexual activity unsafe. Sudden vision loss has occurred in a small number of people taking medicines like tadalafil (Viagra or others).
What side effects can this medicine cause?
The impact of female genital mutilation on sexual function: a study conducted in rural Sudan. Somalian women with female genital mutilation had increased risk of female sexual dysfunction: a cross-sectional observational study. Borghi C, Dell’Atti L. Tadalafil once daily: narrative review of a treatment option for female sexual dysfunctions in midlife and older women. The role of androgens in female sexual dysfunction.
Publisher’s Note
Female genital cutting: impact on women’s health. Sun X, Li C, Jin L, Fan Y, Wang D. Development and validation of Chinese version of the female sexual function index. Evaluation of genital self-image and sexual dysfunction in women with vulvar lichen planus or lichen sclerosus. Biostatistics 102: quantitative data—parametric and non-parametric tests.
Tadalafil for female sexual dysfunction
Efferson C, Vogt S, Elhadi A, Ahmed Hel F, Fehr E. Female genital cutting is not a social coordination norm. In: Diagnostic and statistical manual of mental disorders. Washington, DC: American Psychiatric Association; 2000. p. Most of these people already had certain eye problems or risk factors for blood vessel disorders (heart disease, diabetes, high blood pressure, high cholesterol, coronary artery disease, smoking, or being over 50 years old).