16 HOW SUPPLIED/STORAGE AND HANDLING
It is especially important to tell your healthcare provider if you take: Liqrev contains sildenafil, which is the same medicine found in another medicine called Viagra® which is used for the treatment of erectile dysfunction. Do not take Viagra or other PDE-5 inhibitors including avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra) during treatment with Liqrev. It is not known if sildenafil is safe and effective in children younger than 1 year of age. Tell your doctor if you are pregnant. It is not known whether sildenafil will harm an unborn baby.
| Region | Estimated Market Size (2023) | Growth Rate | Key Players | Typical Uses Scope |
|---|---|---|---|---|
| North America | $150 million | 5% annually | Pfizer, Cipla, Teva | ED, pulmonary hypertension |
| Europe | $100 million | 4.5% annually | Bayer, Sun Pharma | Pulmonary hypertension, off-label uses |
| Asia-Pacific | $200 million | 7% annually | Cipla, Aurobindo, Zydus | Broader use, pediatric cases |
| Rest of World | $50 million | 3.5% annually | Various local manufacturers | Growing awareness and approval |
However, having pulmonary arterial hypertension (PAH) during pregnancy may cause complications such as heart failure, stroke, or medical problems in both mother and baby. The benefit of treating PAH with Liqrev may outweigh any risks to the baby.
| Precaution/Contraindication | Details | Advice |
|---|---|---|
| Nitrate use | Contraindicated with sildenafil | Risk of severe hypotension |
| Cardiovascular disease risk | Use with caution | Consult cardiologist before use |
| Liver or kidney impairment | Dose adjustment needed | Monitor liver/kidney function tests |
| Allergies to sildenafil or excipients | Check ingredients before administration | Discontinue if allergic reactions occur |
It may not be safe to breastfeed while using this medicine. Take this medicine exactly as it was prescribed for you. Follow all directions on your prescription label and read all medication guides or instruction sheets. Shake the bottle for at least 10 seconds before you measure your dose. Measure your prescribed dose using an oral dosing syringe. Your dose may be changed by your healthcare provider. Do NOT change your dose or stop taking this medicine without talking to your healthcare provider.
Pregnancy & Lactation
Liqrev, received FDA approval on April 28, 2023. Do not take Liqrev if you take nitrate medicines either regularly or occasionally, as this can increase your risk of having serious and sudden low blood pressure. Nitrates medicine may include nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas).
5.6 Combination with Other PDE-5 Inhibitors
Stop using Liqrev and get emergency medical help if you have sudden vision loss. You should not use Liqrev if you are allergic to sildenafil, or: if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas). Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as sildenafil generic amyl nitrate or nitrite ("poppers"). Liqrev is usually taken three times a day. Usual Adult Liqrev Dose for Pulmonary Hypertension 20 mg orally three times a day Use: Treatment of PAH (WHO Group I) in adults to improve exercise ability and delay clinical worsening. Liqrev is available as 10 mg/mL oral suspension. If you miss a dose, take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
| Side Effect | Frequency | Severity | Management |
|---|---|---|---|
| Headache | Common | Mild | Analgesics, hydration |
| Flushing | Common | Mild | Cool environment, monitor |
| Nasal congestion | Common | Mild | Decongestants, hydration |
| Dizziness | Less common | Moderate | Avoid sudden movements |
| Vision disturbances | Rare | Moderate | Discontinue, consult physician |
| Priapism (prolonged erection) | Rare | Severe | Emergency medical attention |
Drinking alcohol with this medicine can cause side effects. Grapefruit may interact with this medicine and lead to unwanted side effects.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 100mg | 20 Pills | 45.58€ 43.41€ | |
| Viagra Generic | 50mg | 270 + 8 Pills | 198.48€ 189.03€ | |
| Viagra Generic | 100mg | 60 + 4 Pills | 96.36€ 91.77€ | |
| Viagra Generic | 25mg | 120 + 6 Pills | 125.56€ 119.58€ | |
| Kamagra Oral Jelly | 100mg | 10 Sachets | 54.55€ 51.95€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Viagra Generic | 150mg | 180 + 10 Pills | 236.46€ 225.20€ | |
| Kamagra Polo | 100mg | 120 + 6 Pills | 327.15€ 311.57€ | |
| Kamagra | 100mg | 32 Pills | 121.24€ 115.47€ | |
| Kamagra | 100mg | 60 + 4 Pills | 201.34€ 191.75€ | |
| Viagra Generic | 100mg | 30 + 4 Pills | 60.91€ 58.01€ | |
| Viagra Generic | 25mg | 60 + 4 Pills | 71.99€ 68.56€ |
Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor. Get emergency medical help if you have signs of an allergic reaction to this medicine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Liqrev and get emergency medical help if you have: heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; vision changes or sudden vision loss; or erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis).
Liqrev side effects
Taking sildenafil with nitrate medicine can cause a sudden and serious decrease in blood pressure. To make sure Liqrev is safe for you, tell your doctor if you have ever had: heart problems (chest pain, a heart rhythm disorder, heart attack) retinitis pigmentosa (an inherited condition of the eye) have ever had hearing problems such as ringing in the ears, dizziness, or loss of hearing a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia a physical deformity of the penis (such as Peyronie's disease). Sildenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. It is not clear whether this medicine is the actual cause of vision loss. Call your doctor at once if you have: severe shortness of breath, cough with foamy mucus; ringing in your ears, or sudden hearing loss; swelling in your hands, ankles, or feet; a light-headed feeling, like you might pass out.
- Sildenafil interacts with alpha-blockers, leading to hypotension.
- The syrup should be measured with a proper dosing device.
- The syrup form is less common and might have inconsistent absorption.
- Researchers are exploring alternative delivery methods like liquids.
- Pharmaceutical companies rarely produce sildenafil syrup commercially.
abnormal vision (blurred vision, changes in color vision) muscle pain, back pain; or upset stomach. This is not a complete list of side effects and others may occur.
5.2 Worsening Pulmonary Vascular Occlusive Disease
For pulmonary arterial hypertension, the dose varies by age and weight and is usually taken three times a day, spaced 4 to 6 hours apart. Always follow your doctor’s specific instructions for safe and effective use. Store at room temperature between 15°C and 30°C. Keep bottle tightly closed when not in use. Do not freeze; protect from extreme cold temperatures.
What are the serious side effects of sildenafil?
Avoid direct sunlight and exposure to heat sources. Keep away from moisture, including bathroom storage areas. Store out of reach of children and pets. Discard unused medicine after expiration or doctor’s advice. Generic name: sildenafil Dosage form: Oral suspension (10 mg/mL) Drug class: Agents for pulmonary hypertension The Liqrev brand name has been discontinued in the U.S.
Limitation of Warranty & Liability
If generic versions of this product have been approved by the FDA, there may be generic equivalents available. Liqrev (sildenafil) suspension is used for pulmonary arterial hypertension (PAH) to improve adult patients' ability to exercise and to delay clinical worsening. Liqrev works by relaxing the muscles in blood vessels so they become wider this lowers blood pressure in the lungs, and it also increases the amount of blood pumped by the heart (cardiac output). Liqrev is a phosphodiesterase-5 (PDE-5) inhibitor that has its effect by blocking the enzyme PDE-5. Liqrev is available as an oral suspension that is taken three times a day. Do not take Liqrev with similar medications such as avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra).
- Sildenafil works by relaxing blood vessels to improve blood flow.
- Used primarily to treat erectile dysfunction and pulmonary hypertension.
- Syrup formulations may be used in children or those with swallowing difficulties.
- Proper storage of sildenafil syrup is essential to maintain efficacy.
- It is important to follow a healthcare provider’s instructions when using.
Tell your doctor about all other medications you use. Tell your doctor about all your other medicines, especially: drugs to treat high blood pressure or a prostate disorder; medicine to treat HIV/AIDS - ritonavir and others. Other drugs may interact with sildenafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here. Store Liqrev oral suspension at room temperature between 68°F to 77°F (20°C to 25°C). Use the bottle within 90 days once it has been opened. Liqrev is distributed by: CMP Pharma, Inc. Farmville, NC 27828.
4. Contraindications
Store this medication at room temperature, away from light and moisture. It's important to discuss all medications with your healthcare provider if you are pregnant or breastfeeding. They will be able to advise you on the safest course of action. Sildenafil for oral suspension is a medication used to treat erectile dysfunction (ED) in men in Canada, the US, or other countries. It contains the active ingredient Sildenafil Citrate, a phosphodiesterase type 5 (PDE5) inhibitor.
What should I know about sildenafil before taking it?
This medication works by relaxing the blood vessels in the penis, allowing more blood to flow into the area and helping men achieve and maintain an erection. Sildenafil for oral suspension is taken orally, typically 30 minutes to 1 hour before sexual activity. It is important to note that sexual stimulation is required for the medication to work and that it should not be taken by men who do not have ED. It is also important to consult a healthcare provider before taking this medication. Sildenafil for oral suspension is manufactured by Camber Pharmaceuticals INC.
Medical Professionals
Sildenafil for oral suspension works by blocking the enzyme phosphodiesterase type 5 (PDE5), which helps relax and widen the blood vessels. In erectile dysfunction, this action increases blood flow to the penis during sexual stimulation, enabling an erection. In pulmonary arterial hypertension (PAH), it lowers blood pressure in the lungs by improving blood flow, easing the heart’s workload and enhancing physical ability. Flushing (warmth, redness in face or neck) The dosage of Sildenafil for oral suspension depends on the condition being treated, age, and medical history. For erectile dysfunction in adults, a typical starting dose is 50 mg, taken about 30 to 60 minutes before sexual activity, not more than once daily. Sildenafil for Oral Suspension by is a Prescription medication manufactured, distributed, or labeled by Novadoz Pharmaceuticals LLC, AptaPharma, Inc. Drug facts, warnings, and ingredients follow. Table of Contents FULL PRESCRIBING INFORMATION: CONTENTS*1 INDICATIONS AND USAGE2 DOSAGE AND ADMINISTRATION2.1 Sildenafil for Oral Suspension2.3 Reconstitution of the Powder for Oral Suspension3 DOSAGE FORMS AND STRENGTHS4 CONTRAINDICATIONS5 WARNINGS AND PRECAUTIONS5.1 Mortality with Pediatric Use5.2 Hypotension5.3 Worsening Pulmonary Vascular Occlusive Disease5.4 Epistaxis5.5 Visual Loss5.6 Hearing Loss5.7 Combination with other PDE-5 inhibitors5.8 Priapism5.9 Vaso-occlusive Crisis in Patients with Pulmonary Hypertension Secondary to Sickle Cell Anemia6 ADVERSE REACTIONS6.1 Clinical Trials Experience6.2 Postmarketing Experience7 DRUG INTERACTIONS8 USE IN SPECIFIC POPULATIONS8.1 Pregnancy8.2 Lactation8.4 Pediatric Use8.5 Geriatric Use8.6 Patients with Hepatic Impairment8.7 Patients with Renal Impairment10 OVERDOSAGE11 DESCRIPTION12 CLINICAL PHARMACOLOGY12.1 Mechanism of Action12.2 Pharmacodynamics12.3 Pharmacokinetics13 NONCLINICAL TOXICOLOGY13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility14 CLINICAL STUDIES16 HOW SUPPLIED/STORAGE AND HANDLING17 PATIENT COUNSELING INFORMATION* Sections or subsections omitted from the full prescribing information are not listed.