8 USE IN SPECIFIC POPULATIONS
However, its overall efficacy is not clear. Sildenafil has been studied for high-altitude pulmonary edema (HAPE), but its use is currently not recommended for that indication. In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision.
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[5][8][11][12] In 2023, it was the 151st most commonly prescribed medication in the United States, with more than 3 million prescriptions. [13][14] It is available as a generic medication. [15][16] In the United Kingdom, it is available as a pharmacy medicine. The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete sexual intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for males with diabetes mellitus.
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Tentative evidence suggests that sildenafil may help males who experience antidepressant-induced erectile dysfunction. While sildenafil improves sildenafil citrate 100mg tablets some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects. Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon;[9][21] these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes. [9] As of 2016,[update] their role more generally in Raynaud's was not clear. Sildenafil has shown some potential for improving exercise performance at high altitudes. [4] Some sildenafil users have complained of seeing everything tinted blue (cyanopsia).
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Oral Jelly | 100mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Kamagra Polo | 100mg | 60 + 4 Pills | 189.39€ 180.37€ | |
| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ | |
| Viagra Generic | 150mg | 360 + 10 Pills | 423.48€ 403.31€ | |
| Viagra Generic | 100mg | 270 + 10 Pills | 270.47€ 257.59€ | |
| Kamagra Oral Jelly | 100mg | 63 + 7 Sachets | 224.18€ 213.50€ | |
| Kamagra Soft Tabs | 100mg | 120 + 6 Pills | 311.78€ 296.93€ | |
| Kamagra | 100mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Viagra Generic | 200mg | 10 Pills | 40.96€ 39.01€ | |
| Kamagra | 100mg | 60 + 4 Pills | 201.34€ 191.75€ | |
| Viagra Generic | 200mg | 270 + 10 Pills | 379.76€ 361.68€ | |
| Viagra Generic | 25mg | 120 + 6 Pills | 125.56€ 119.58€ |
[24] This cyanopsia can be explained because sildenafil, while selective for PDE5, does have some affinity for PDE6, which is the phosphodiesterase found in the retina. Patients thus taking the drug may experience colorvision abnormalities. Some complained of blurriness and loss of peripheral vision. In July 2005, the US Food and Drug Administration (FDA) updated labeling for tadalafil (Cialis), vardenafil (Levitra), and sildenafil (Viagra) to reflect a small number of post-marketing reports of sudden vision loss, while acknowledging that "...it is not possible to determine whether these oral medicines for erectile dysfunction were the cause of the loss of eyesight or whether the problem is related to other factors such as high blood pressure or diabetes, or to a combination of these problems.
6.1 Clinical Trials Experience
Never disregard professional advice or delay seeking it based on the information you read here. Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4][8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9] It is unclear if it is effective for treating sexual dysfunction in females. [8] It can be taken orally (swallowed by mouth), intravenously (injection into a vein), or through the sublingual route (dissolved under the tongue).
Common Side Effects
[8][10] Onset when taken orally is typically within twenty minutes and lasts for about two hours. Common side effects include headaches, heartburn, and flushed skin. [8] Caution is advised in those with cardiovascular disease. [8] Rare but serious side effects include vision problems, hearing loss, and prolonged erection (priapism) that can lead to damage to the penis. [8] Sildenafil should not be taken by people on nitric oxide donors such as nitroglycerin, as this may result in a serious drop in blood pressure.
Warnings for other groups
Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. [8] It requires sexual arousal to work, and does not by itself cause or increase sexual arousal. [8] It also results in dilation of the blood vessels in the lungs. Pfizer originally discovered the medication in 1989 while looking for a treatment for angina. [11] It was approved for medical use in the United States and in the European Union in 1998. "[25] A careful review of pooled data from clinical trials containing well documented information about the dose and duration of exposure to the drug for a large number of patients, yields no evidence for an increased risk of non-arteritic anterior ischemic optic neuropathy or other adverse ocular events associated with PDE5 inhibitor use.
| Medication Class | Interaction Effect | Notes |
|---|---|---|
| Nitrates | Severe hypotension | Absolute contraindication |
| Alpha-blockers | Enhanced blood pressure lowering | Use with caution |
| CYP3A4 Inhibitors (e.g., Ketoconazole) | Increased sildenafil levels | Dose adjustment needed |
| Protease Inhibitors | Increased risk of side effects | Monitor patient closely |
| Other PDE5 inhibitors | Additive effects | Not recommended to combine |
Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss.
- Sildenafil was originally developed to treat hypertension before ED use.
- The brand names include Viagra, Revatio, among others.
- Generic sildenafil is available at a lower cost with the same efficacy.
[4] In October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. [4] Other drugs that interfere with the metabolism of sildenafil include erythromycin and cimetidine, both of which can also lead to prolonged plasma half-life levels. The use of sildenafil and an α1 blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Concomitant use of nitric oxide donors, organic nitrites and nitrates,[30] such as: nitroglycerinisosorbide mononitrateisosorbide dinitratesodium nitroprussidealkyl nitrites (commonly known as "poppers") Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors.
See also:
Do Sildenafil Tablets IP 50 mg cause low blood pressure? Sildenafil Tablets IP 50 mg may cause low blood pressure, leading to dizziness on standing. If this occurs, avoid standing up or walking suddenly; lie down and rise slowly only when you feel better. You can take Sildenafil Tablets IP 50 mg with or without food. However, taking sildenafil with a high-fat meal may delay its onset of action.
Sildenafil Oral Film for ED
Therefore, you are advised to take Sildenafil Tablets IP 50 mg with light meals. Can I take 2 doses of Sildenafil Tablets IP 50 mg for better results? Never take 2 sildenafil citrate tablets for female doses at the same time. It could lead to severe adverse events. Can I get Sildenafil Tablets IP 50 mg without a prescription?
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
Sildenafil Tablets IP 50 mg are only available with a prescription. Can I take Sildenafil Tablets IP 50 mg for premature ejaculation? Sildenafil Tablets IP 50 mg are effective in treating premature ejaculation (PE), but should only be used when prescribed by a doctor. The information provided on this website is for general informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always consult with a physician or qualified healthcare provider for any medical concerns. Sildenafil's popularity with young adults has increased over the years. [32] Sildenafil's brand name, Viagra, is widely recognized in popular culture, and the drug's association with treating erectile dysfunction has led to its recreational use.
2.5 Dosage Adjustments in Special Populations
Do not take Sildenafil with nitrates (medicines for chest pain) or nitric oxide donors, as this can cause a dangerous drop in blood pressure. Use caution if taking blood pressure-lowering medicines or alpha-blockers; consult your doctor for advice. If you experience sudden vision loss or a sudden decrease in vision, stop taking Sildenafil immediately and seek medical attention. Sildenafil may cause low blood pressure, leading to dizziness or fainting, especially when standing up quickly. Rise slowly from sitting or lying positions.
Why it’s used
Store at a temperature below 86°F (30 °C). It is primarily used to treat erectile dysfunction in adult men and pulmonary arterial hypertension in adults. How do Sildenafil Tablets IP 50 mg help treat erectile dysfunction? It relaxes blood vessels in the penis, allowing increased blood flow during sexual arousal, which helps achieve an erection. Taking Sildenafil with nitrates or nitroglycerin can cause severe and potentially life-threatening low blood pressure.
Who is Sildenafil 50mg suitable for?
Can I take blood pressure-lowering medicines with Sildenafil Tablets IP 50 mg? Sildenafil can lower blood pressure, and combining it with other blood pressure-lowering drugs may cause excessive hypotension. Do Sildenafil Tablets IP 50 mg cause vision disturbances? Rarely, Sildenafil may cause sudden vision loss or disturbances. If this occurs, stop the medication and seek immediate medical help. [33] The reasons behind such use include the belief that the drug increases libido, improves sexual performance,[33] or permanently increases penis size. [34] Studies on the effects of sildenafil when used recreationally are limited, but suggest it has little effect when used by those who do not have erectile dysfunction.
| Country/Region | Approval Status | Regulatory Body | Notes |
|---|---|---|---|
| United States | Approved | FDA | As prescription medication |
| European Union | Approved | EMA | Available as prescribed |
| Canada | Approved | Health Canada | Prescription only |
| Australia | Approved | TGA | Strict prescribing guidelines |
| India | Approved | CDSCO | Widely used, generic versions available |
In one study, a 25 mg dose was shown to cause no significant change in erectile quality, but did reduce the postejaculatory refractory time. [35] This study also noted a significant placebo effect in the control group. Unprescribed recreational use of sildenafil and other PDE5 inhibitors is noted as particularly high among users of illegal drugs.
- Sildenafil may cause dizziness; avoid operating machinery after taking.
- Monitor for any adverse reactions and report to your doctor.
- Use with caution if you have pre-existing conditions like low blood pressure.
[36] Sildenafil is sometimes used to counteract the effects of other substances, often illicit. [33] Some users mix it with methylenedioxymethamphetamine (MDMA, ecstasy), other stimulants, or opiates in an attempt to compensate for the common side effect of erectile dysfunction, a combination known as "sextasy", "rockin' and rollin'", "hammerheading", or "trail mix".