DOSAGE FORMS AND STRENGTHS
For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of sildenafil in children younger than 1 year of age. Safety and efficacy have not been established. Sildenafil should never be used in children for erectile dysfunction. In general, sildenafil should not be used for pulmonary arterial hypertension in children, especially for chronic use. Use of sildenafil oral film is not indicated for use in the pediatric population.
| Parameter | Description | Typical Values | Notes |
|---|---|---|---|
| Absorption | Time to peak plasma concentration (Tmax) | 30-120 minutes | Taken on an empty stomach for faster absorption |
| Bioavailability | Percentage absorbed into bloodstream | 40% | Affected by food intake |
| Half-life | Duration for plasma concentration to reduce by half | 4 hours | Determines dosing frequency |
| Metabolism | Liver enzyme involved | CYP3A4 | Also metabolized by CYP2C9 |
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sildenafil in the elderly.
Advice To Patients
Cenforce Sildenafil 50 Tablets is used in the treatment of premature ejaculation in adult men. It increases blood flow to the penis to help men get an erection. This medicine should be used only when prescribed by a doctor. Hiforce Sildenafil 100 mg Oral Jelly is a prescription medicine used to treat erectile dysfunction (impotence) in men. The jelly form is easy to use with great taste.
How do PDE5 inhibitors work (Sildenafil, Tadafil, Vardenafil)?
Kamagra Sildenafil 100 mg Oral Jelly is a prescription medicine used to treat erectile dysfunction (impotence) in men. Filagra Sildenafil 100 mg Oral Jelly is a prescription medicine used to treat erectile dysfunction (impotence) in men. Kamagra sildenafil 25mg tablets Sildenafil 50 mg Oral Jelly is a prescription medicine used to treat erectile dysfunction (impotence) in men. Eregra Sildenafil Citrate Tablets is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). With thorough knowledge of the industry, we are engaged in manufacturing and supplying Sildenafil Citrate 50 mg Tablets.
Azole Antifungals
The sildenafil tablets offered by us are widely used for treating erection dysfunction in men by inhibiting CGMP-specific phosphodiesterase type 5. All these sildenafil tablets are formulated in tandem with the norms of the industry by using superior quality ingredients procured from the certified vendors of the market. While formulating these sildenafil tablets, our professionals strictly follow the established norms of the industry. Some of the features of these sildenafil tablets are mentioned as follows: Sildenafil Citrate 200 mg Tablets is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). Mahipat Patel (Director) Centurion Laboratories Private LimitedBiotech Park Gidc, P-2, Manjusar, Savli, Vadodara Vadodara - 391770, Gujarat, India Sildenafil is used to treat erectile dysfunction (also called sexual impotence). However, elderly patients are more likely to have age-related liver, kidney, sildenafil cenforce or heart problems, which may require caution and an adjustment in the dose for patients receiving sildenafil. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
- Sildenafil 200 mg is not suitable for everyone; consult a doctor beforehand.
- Overdose can lead to serious risks like vision loss or prolonged erections.
- The medication should be stored in a cool, dry place away from children.
- It can interact with other medications, including blood thinners and antihypertensives.
- Sildenafil enhances the effects of nitric oxide, relaxing blood vessels.
- Patients should avoid heavy meals before taking sildenafil 200 mg.
In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 200mg | 180 + 10 Pills | 277.56€ 264.34€ | |
| Viagra Generic | 50mg | 60 + 4 Pills | 83.93€ 79.93€ | |
| Viagra Generic | 50mg | 30 + 4 Pills | 54.26€ 51.68€ | |
| Viagra Generic | 150mg | 360 + 10 Pills | 423.48€ 403.31€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Kamagra | 100mg | 20 Pills | 86.09€ 81.99€ | |
| Viagra Generic | 50mg | 90 + 6 Pills | 107.37€ 102.26€ | |
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ | |
| Viagra Generic | 100mg | 10 Pills | 28.91€ 27.53€ | |
| Viagra Generic | 150mg | 120 + 8 Pills | 177.58€ 169.12€ | |
| Viagra Generic | 200mg | 60 + 4 Pills | 125.19€ 119.23€ | |
| Viagra Generic | 150mg | 10 Pills | 36.73€ 34.98€ | |
| Viagra Generic | 150mg | 90 + 6 Pills | 147.18€ 140.17€ | |
| Viagra Generic | 25mg | 60 + 4 Pills | 71.99€ 68.56€ |
Using this medicine with any of the following medicines is not recommended.
Key Highlights
Sildenafil works on the PDE5 enzyme in the lungs to relax the blood vessels. This will increase the supply of blood to the lungs and reduce the workload of the heart. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you.
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Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection.
Common Adverse Effects
By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked. Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection. Sildenafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension. This is a type of high blood pressure that occurs between the heart and the lungs. When hypertension occurs in the lungs, the heart must work harder to pump enough blood through the lungs. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases.
| Patient Group | Recommended Dosage | Administration Tips | Contraindications |
|---|---|---|---|
| Adult Men with ED | 200 mg once daily | Take 30-60 min before activity | Nitrate medication use, severe liver impairment |
| Pulmonary Hypertension | 20 mg three times daily | Take with water, on an empty stomach | Concurrent use of compatible medications |
| Elderly Patients | Start with lower doses | Adjust based on response | Liver or kidney impairment |
| Patients with Kidney Disease | Dose adjustment may be needed | Follow physician instructions | Severe renal impairment |
If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Abnormal penis, including a curved penis or birth defects of the penis—Chance of problems occurring may be increased and this medicine should be used with caution in these patients. Arrhythmia (irregular heartbeat, within the last 6 months) or Blood vessel problems (eg, aortic stenosis, idiopathic subaortic stenosis) or Heart attack (within the last 6 months) or Retinitis pigmentosa (an inherited eye disorder) or Stroke (within the last 6 months)—Should not be used in patients with these conditions. Crowded disc or low cup to disc ratio in the eye (an eye disorder) or Hyperlipidemia (high fats in the blood) or Non-arteritic anterior ischemic optic neuropathy or NAION (serious eye condition), history of or Retinitis pigmentosa (an inherited eye disorder) or Smoking—May increase the chance for a serious side effect in the eye called NAION. Stomach ulcer, or history of or—Chance of problems occurring may be increased.
- Sildenafil 200 mg's safety profile depends on individual health conditions.
- It is important to inform your doctor of all medications being taken.
- Use sildenafil only when needed for sexual activity.
- Avoid engaging in activities that require alertness until effects are known.
- The drug is often part of a broader erectile dysfunction treatment strategy.
- Safe storage is essential to prevent accidental ingestion by children or others.
It is not known if the medicine is safe for use in these patients. The effects may be increased because of slower removal of the medicine from the body.
| Side Effect | Frequency | Severity | Management Suggestions |
|---|---|---|---|
| Headache | Common | Mild | Analgesics, hydration |
| Visual disturbances | Less common | Mild-moderate | Discontinue use if persistent |
| Dizziness | Common | Mild | Sit or lie down, avoid driving |
| Priapism | Rare | Severe | Seek immediate medical attention |
| Hearing loss | Very rare | Severe | Discontinue medication, seek help |
Sickle-cell anemia (blood disorder)—Sildenafil should be used with caution in these patients as problems with prolonged erection of the penis may occur. Pulmonary arterial hypertension (high blood pressure in the lungs) or Pulmonary veno-occlusive disease or PVOD (a type of lung disease)—Use with caution. Use sildenafil exactly as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered.
More about sildenafil
The maximum effect is observed when the tablet is taken one hour before.Precautions: Sildenafil Citrate manufactures in India mentioned a detailed list of precautions and side-effect in the product leaflet. Amongst the prominent precautions, people having severe low and high blood pressure rating, heart problemsshould avoid the drug. The drug doesn’t protect from sexually transmitted diseases like HIV, Hepatitis B, Syphilis and Gonorrhea. Those who have life-threatening diseases like sickle cell Anemia, multiple myeloma or leukemia should avoid Sildenafil Citrate. Those who have problems like peptic ulcer, retinitis pigmentosa, and bleeding disorder should seek medical advice.
5.7 Combination with other PDE5 Inhibitors or Other Erectile Dysfunction Therapies
An erection that remains persistent after four hours or more needs to be consulted immediately. It could cause severe damage to the penis. Sildenafil Citrate distributors in India should follow an effective mechanism of communicating physicians about the side-effects of Sildenafil Citrate. Though several trials have been conducted so far to evaluate the effect of this drug, they can't be called clinical trials in the actual sense. However, it reveals that it is a quite effective drug in resolving erectile dysfunction amongst men.
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The incidence of adverse reaction increased with dose. The discontinuation rate because of adverse reactions is around 2.5 percent which is not unusual. Also, the medical history, allergies, and other complications must be known to the physician before prescribing the medicine. Not only in India, but a Sildenafil Citrate exporter in India gets bulk orders from other countries as well. Thus, the market for the drug is lucrative and profitable. If too much is used, the chance of side effects is increased. This medicine comes with a patient information leaflet. Read and follow these instructions carefully before you start using sildenafil and each time you get a refill of your medicine. Ask your doctor if you have any questions.
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