Comparing Available Treatments for Female HSDD
Physiologic Measures of Sexual Function in Women: A Review. Topical Pentoxifylline for Pressure Injury Prevention: A Call for Clinical Research. Advances in skin & Wound Care, 32(11), 486. The effect of topically applied vasoactive agents and testosterone versus testosterone in the treatment of erectile dysfunction in aged men with low sexual interest. International Journal of Impotence Research, 13(2), 93–99. Chemical composition, olfactory evaluation and antioxidant effects of essential oil from Mentha x piperita. Natural Product Communications, 4(8), 1107–1112.
| Off-Label Use | Potential Risks | Medical Advice |
|---|---|---|
| Sildenafil for Female Libido | Cardiovascular side effects, interactions with other meds | Always consult a doctor before use |
| Non-approved supplements | Unknown composition, higher risk of adverse reactions | Use only if prescribed by a healthcare professional |
| DIY formulations | Dangerous, no clinical testing | Highly discouraged |
Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers. Clitoral blood flow after use of gel containing L-arginine and L-citrulline. Turnera diffusa Wild (Turneraceae) recovers sexual behavior in sexually exhausted males. Journal of Ethnopharmacology, 123(3), 423–429.
- Filbanserin can cause dizziness, sleepiness, nausea, and low blood pressure.
- It has serious interactions with alcohol and certain medications like antifungals.
- Bremelanotide side effects include nausea, vomiting, and temporary skin darkening.
- Ospemifene may increase the risk of blood clots and cause hot flashes.
- Testosterone therapy can cause acne, unwanted hair growth, and voice changes.
- Topical estrogen has minimal systemic absorption but can cause local irritation.
- All prescription treatments require a careful risk-benefit analysis with a doctor.
Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review. Mayo Clinic Proceedings, 92(1), 114–128.
- Filbanserin typically takes 4-8 weeks of daily use to show any potential effect.
- Bremelanotide is used as needed, with an injection approximately 45 minutes before sex.
- Effects of a single Vyleesi injection are intended to last for about 8-12 hours.
- Ospemifene is a daily tablet that requires ongoing use to maintain its effects.
- Topical estrogen treatments often show improvement in dryness within a few weeks.
- Testosterone therapy may take several months to potentially influence libido.
- Psychological therapies require a longer-term commitment for sustainable results.
Flibanserin for Premenopausal Hypoactive Sexual Desire Disorder: Pooled Analysis of Clinical Trials. Journal of Women's Health (2002), 28(6), 769–777. Melanocortin 4 receptor agonism enhances sexual brain processing in women with hypoactive sexual desire disorder. Peripheral Female Genital Arousal as Assessed by Thermography Following Topical Genital Application of Alprostadil vs Placebo Arousal Gel: A Proof-of-Principle Study Without Visual Sexual Stimulation. Effect of Diindolylmethane on Estrogen-related Hormones, Metabolites and Tamoxifen Metabolism: Results of a Randomized, Placebo-controlled Trial.
| Brand Name | Active Ingredient | Approval Status | Price Range (£) | Availability |
|---|---|---|---|---|
| Enhancify | Flibanserin | Approved | 35 - 65 | Limited stock |
| FemaleMax | Bremelanotide | Not approved UK | N/A | Online only |
| LibidoBoost | Sildenafil | Off-label use | 25 - 45 | Pharmacy |
| DesirePlus | Melanotan II | Not approved | .n/a | Online markets |
Cancer Epidemiology Biomarkers & Prevention 1, 26(3), 435. Flibanserin (Addyi): The First FDA-Approved Treatment for Female Sexual Interest/Arousal Disorder in Premenopausal Women. Role of Nitric Oxide in the Cardiovascular and Renal Systems.
Find out if treatment is right for you.
Endothelial Nitric Oxide Synthase Regulation in Female Genital Tract Structures. The Journal of Sexual Medicine, 6, 247-253. Yes, you can have better sex in midlife and in the years beyond. Testosterone therapy in women: Does it boost sex drive? Treatment of Hypoactive Sexual Desire Disorder Among Women: General Considerations and Pharmacological Options.
What causes low libido in women?
Focus: Journal of Life Long Learning in Psychiatry, 19(1), 39-45. Integrative Medicine (Fourth Edition), 592-599.e2. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Effects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained males. Journal of Exercise Nutrition & Biochemistry, 22(4), 7-19. International Journal of Molecular Sciences, 19(9), 2605. Systematic review and meta-analysis of phosphodiesterase type 5 inhibitors for the treatment of female sexual dysfunction.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ | |
| Viagra Generic | 25mg | 360 + 10 Pills | 213.68€ 203.50€ | |
| Viagra Oral Jelly | 100mg | 30 + 5 Sachets | 115.76€ 110.25€ | |
| Viagra Super Active | 100mg | 10 Pills | 28.76€ 27.39€ | |
| Viagra Generic | 100mg | 360 + 10 Pills | 330.21€ 314.49€ | |
| Viagra Original | 100mg | 34 + 2 Pills | 163.67€ 155.88€ | |
| Viagra Professional | 100mg | 270 + 6 Pills | 456.97€ 435.21€ | |
| Viagra Professional | 100mg | 60 + 2 Pills | 146.74€ 139.75€ | |
| Viagra Soft Tabs | 100mg | 30 + 4 Pills | 83.06€ 79.10€ | |
| Viagra Super Active | 100mg | 360 + 30 Pills | 470.93€ 448.50€ | |
| Viagra Generic | 50mg | 90 + 6 Pills | 107.37€ 102.26€ |
International Journal of Gynecology & Obstetrics, 133(2), 139-145.
The Sexy Science Behind Dare to Play
Versus a placebo, researchers reported that Vyleesi “significantly increased sexual desire.”56 To take Vyleesi, you use the autoinjector pen to give yourself an injection under the skin on your thighs or stomach about 45 minutes before sexual activity. The manufacturer notes that it shouldn’t be used more than once per day or more than eight times per month. The active ingredient in Vyleesi is bremelanotide, an FDA-approved drug to treat HSDD. It’s important to note that this medication does bring about the possibility of side effects, including (but not limited to):7 Because Vyleesi can alter your heart rate and blood pressure, it isn’t recommended for people with hypertension or cardiovascular issues. Even if you don’t have those concerns, it’s important to speak with your primary care provider to ensure Vyleesi is safe for you.
Comparison table
You can obtain a Vyleesi prescription either through your doctor or the manufacturer’s third-party telehealth partner, Prescribery, for a $29 consultation fee (just click the “Get Vyleesi Online” button on the top of the Vyleesi website). No matter where you receive your prescription from, it will be shipped to you for free from BlinkRx, a specialty pharmacy. If you have insurance, the cost of Vyleesi may be covered. It’s a good idea to check with your plan beforehand to verify. If you don’t have insurance, Vyleesi offers financial assistance through an application on the prescription information website. Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial. (308) Oxytocin Troches as an Adjunctive Intervention to Conventional Testosterone and Erectile Dysfunction Medication for Men with Sexuality Concerns.
Ready to see why DARE to PLAY could be the best you've ever had?
You need to be at least 18 years old and not insured by a government agency (such as Medicaid) to be eligible for financial aid. Innerbody uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Clayton, A. H., Goldstein, I., Kim, N.
What is FSAD?
N., Althof, S. E., Faubion, S. S., Faught, B. M., Parish, S. J., Simon, J. The Journal of Sexual Medicine, 20(Supplement_1).
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Topics in Current Chemistry, 328, 155–240. Seminal plasma magnesium and premature ejaculation: a case-control study. The Role of Magnesium in Hypertension and Cardiovascular Disease. The Journal of Clinical Hypertension, 13(11), 843-847. Effect of Zinc on Testosterone Levels and Sexual Function of Postmenopausal Women: A Randomized Controlled Trial.
CONVENIENT & DISCREET
Journal of Sex & Marital Therapy, 47(8), 804–813. BIOCHEMISTRY OF MOBILE ZINC AND NITRIC OXIDE REVEALED BY FLUORESCENT SENSORS. Adverse Events Associated with Melatonin for the Treatment of Primary or Secondary Sleep Disorders: A Systematic Review. Evaluation of Dietary Niacin and New-Onset Hypertension Among Chinese Adults. Hop extracts and hop substances in treatment of menopausal complaints. Tadalafil once daily: Narrative review of a treatment option for female sexual dysfunctions (FSD) in midlife and older women. Tadalafil reversal of sexual dysfunction caused by serotonin enhancing medications in women. Journal of Sex & Marital Therapy, 32(1), 1–3. Tadalafil 5 mg Daily Treatment for Type 1 Diabetic Premenopausal Women Affected by Sexual Genital Arousal Disorder. The Journal of Sexual Medicine, 9(8), 2057-2065. Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study. Safety and influence of a novel extract of fenugreek on healthy young women: A randomized, double-blinded, placebo-controlled study. Evaluation of aphrodisiac activity of ethanol extract of Ganoderma lucidum in male Wistar rats. Translational Andrology and Urology, 11(7), 982. Guaraná's Journey from Regional Tonic to Aphrodisiac and Global Energy Drink. Evidence-Based Complementary and Alternative Medicine: ECAM, 7(3), 279. Effectiveness of guaraná (Paullinia cupana) for postradiation fatigue and depression: results of a pilot double-blind randomized study. Journal of Alternative and Complementary Medicine (New York, N.Y.), 15(4), 431–433.
HOW TO GET YOUR PRESCRIPTION
Hops for Menopausal Vasomotor Symptoms: Mechanisms of Action. Journal of Traditional and Complementary Medicine, 2(4), 331-339. Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial. Menopause (New York, N.Y.), 50mg viagra 23(11), 1252–1256. A systematic review of clinical trials on Ginkgo (Ginkgo biloba) effectiveness on sexual function and its safety.
CUSTOM FORMULATED
Journal of ethnopharmacology, 145(3), 715–721. Capsaicinoids Modulating Cardiometabolic Syndrome Risk Factors: Current Perspectives. The effect of melatonin on the sexual function among postmenopausal women: A randomized placebo-controlled trial. Nursing and Midwifery Studies, 6(4), 149. Understanding Unapproved Use of Approved Drugs "Off Label". Effects of a commercial product containing guaraná on psychological well-being, anxiety and mood: A single-blind, placebo-controlled study in healthy subjects.
| Condition | Description | Typical Treatment Approach | Alternative Options |
|---|---|---|---|
| Hypoactive Sexual Desire Disorder | Low sexual desire in women | Medication, counseling | Therapy, lifestyle changes |
| Postmenopause Libido Loss | Reduced libido after menopause | Hormone therapy, medications | Vaginal lubricants, counseling |
| Sexual Arousal Disorder | Difficulty achieving arousal | Available medications | Relaxation techniques |
Journal of Negative Results in Biomedicine, 12, 9. (023) The Acute Effect of Caffeine on Genital Arousal in Women: A Pilot Study. The Journal of Sexual Medicine, 20(Supplement_2). Crocus sativus (saffron) in the treatment of female sexual dysfunction: A three-center, double-blind, randomized, and placebo-controlled clinical trial. Saffron for treatment of fluoxetine-induced sexual dysfunction in women: Randomized double-blind placebo-controlled study. Human Psychopharmacology: Clinical and Experimental, 28(1), 54-60. Tribulus terrestris for treatment of sexual dysfunction in women: Randomized double-blind placebo-controlled study.
If you're tired of uncertain quality and unproven options, you're not alone.
The International Society for the Study of Women's Sexual Health Process of Care for Management of Hypoactive Sexual Desire Disorder in Women. Mayo Clinic Proceedings, 93(4), 467–487. Female sexual dysfunction (FSD): Prevalence and impact on quality of life (QoL). Mayo Foundation for Medical Education and Research (MFMER). Icahn School of Medicine at Mount Sinai.
Let's do it.
197 A Double-blind, Placebo-controlled, 2-Way Crossover Study Using Thermography to Assess the Pharmacodynamics of Sildenafil Cream, 3.6% in Healthy Women. The Journal of Sexual Medicine, 17(1), S69. Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women. Pharmacy: Journal of Pharmacy Education and Practice, 9(2). Vyleesi Prices, Coupons and Patient Assistance Programs. DARU Journal of Pharmaceutical Sciences, 22(1), 40.
- Online pharmacies like Superdrug Online Doctor offer private consultations.
- Boots Online Doctor provides a similar service for discreet access to treatments.
- LloydsPharmacy Online Doctor allows for private prescriptions following an assessment.
- The NHS provides treatment primarily for underlying causes like depression or menopause.
- Private clinics, such as The London Hormone Clinic, specialize in women's health.
- Costs for private prescriptions vary significantly, often £50-£100 per month.
- Always ensure any online provider is registered with the General Pharmaceutical Council.
Tribulus Terrestris for Female Sexual Dysfunction: A Systematic Review. Tribulus terrestris and female reproductive system health: A comprehensive review. Bioavailability enhancers of herbal origin: An overview. Asian Pacific Journal of Tropical Biomedicine, 3(4), 253. Fenugreek, A Potent Hypoglycaemic Herb Can Cause Central Hypothyroidism Via Leptin - A Threat To Diabetes Phytotherapy.